57183-52-5Relevant academic research and scientific papers
Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy- 2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives
Chen, Yeh-Long,Huang, Chao-Jhieh,Huang, Zun-Yuan,Tseng, Chih-Hua,Chang, Feng-Shuo,Yang, Sheng-Huei,Lin, Shinne-Ren,Tzeng, Cherng-Chyi
, p. 3098 - 3105 (2007/10/03)
The present report describes the synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2- phenylquinoline derivatives. The antiproliferative activity of 4′-COMe-substituted derivatives decrease
A systematic approach to the optimization of substrate-based inhibitors of the hepatitis C virus NS3 protease: Discovery of potent and specific tripeptide inhibitors
Llinàs-Brunet, Montse,Bailey, Murray D.,Ghiro, Elise,Gorys, Vida,Halmos, Ted,Poirier, Martin,Rancourt, Jean,Goudreau, Nathalie
, p. 6584 - 6594 (2007/10/03)
The inadequate efficacy and tolerability of current therapies for the infectious liver disease caused by the hepatitis C virus have warranted significant efforts in the development of new therapeutics. We have previously reported competitive peptide inhib
Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: Identification as antimitotic agents interacting with tubulin
Kuo,Lee,Juang,Lin,Wu,Chang,Lednicer,Paull,Lin,Hamel,Lee
, p. 1146 - 1156 (2007/10/02)
A series of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds have been synthesized and evaluated as cytotoxic compounds and as antimitotic agents interacting with tubulin. The 2-phenyl-4-quinolones (22-30) with substituents
