EC 3.4.22.1

Base Information

• Chemical Name: EC 3.4.22.1
• CAS No.: 9047-22-7
• Molecular Formula: NULL
• Molecular Weight: 0
• Mol file: 9047-22-7.mol

Synonyms:CathepsinB1; Cathepsin II; E.C. 3.4.22.1

Chemical Property of EC 3.4.22.1

Chemical Property:

• Storage Temp.: −20°C
• Solubility.: H2O: soluble1.0mg/mL, clear

Purity/Quality:

98%,99%, ^*data from raw suppliers

CATHEPSIN B 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: B

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• General Description: EC 3.4.22.1, also known as cathepsin B, is a cysteine protease involved in pathological processes such as cancer progression. It exhibits both endopeptidase and exopeptidase activities, contributing to extracellular matrix degradation and tumor cell invasion. Inhibitors targeting this enzyme, like nitroxoline derivatives, are explored for their potential to disrupt these processes, though further optimization is needed to enhance their efficacy.

Refernces

Cathepsin B inhibitors: Further exploration of the nitroxoline core

10.1016/j.bmcl.2018.02.042

The research focuses on the design and synthesis of novel derivatives of nitroxoline as inhibitors of human cathepsin B, a cysteine protease implicated in various pathological processes, including cancer. The study aims to further define the structural requirements for cathepsin B inhibition by nitroxoline derivatives and to provide knowledge that could lead to the development of non-peptidic compounds useful against tumor progression. The researchers synthesized over 60 nitroxoline-based derivatives and evaluated their ability to inhibit both endopeptidase and exopeptidase activities of cathepsin B. They also assessed the compounds' ability to reduce extracellular and intracellular collagen IV degradation and their impact on tumor cell invasion in vitro. The study concluded that while significant improvement in in vitro cathepsin B inhibition was not achieved compared to previous results, several derivatives showed promising efficacy in tumor-cell-based assays. Key chemicals used in the synthesis process included various nitroxoline derivatives, amidoacetonitriles, aminoacetonitriles, and different substituents at positions 2, 7, and 8 of the nitroxoline core, as well as reagents for coupling reactions and nitration procedures.