2-oxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)acetic acid

Base Information

• Chemical Name: 2-oxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)acetic acid
• CAS No.: 727357-57-5
• Molecular Weight: 0
• Mol file: 727357-57-5.mol

Synonyms:2-OXO-1H-PYRROLO[3,2-B]PYRIDINE-3-ACETIC ACID;2-OXO-2-(1H-PYRROLO[3,2-B]PYRIDIN-3-YL)ACETIC ACID

Chemical Property of 2-oxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)acetic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 434.35°C at 760 mmHg
• Flash Point: 216.488°C
• Density: 1.568g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-oxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)acetic acid

There total 1 articles about 2-oxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-oxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)acetate → 2-oxo-2-(1H-pyrrolo[3,2-b]-pyridin-3-yl)acetic acid (727357-57-5)

Guidance literature:

With water; potassium carbonate; In methanol; for 16h;

DOI:10.1021/jm900843g

Reference yield:

(R)-3-methyl-N-benzoylpiperazine hydrochloride (474010-60-1) + 2-oxo-2-(1H-pyrrolo[3,2-b]-pyridin-3-yl)acetic acid (727357-57-5) → (R)-1-(4-benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyrrolo[3,2-b]-pyridin-3-yl)ethane-1,2-dione (357262-85-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm900843g

Downstream raw materials:

(R)-1-(4-benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyrrolo[3,2-b]-pyridin-3-yl)ethane-1,2-dione