(R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE

Base Information

• Chemical Name: (R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE
• CAS No.: 474010-60-1
• Molecular Formula: C12H17ClN2O
• Molecular Weight: 240.733
• Hs Code.: 2933599090
• Mol file: 474010-60-1.mol

Synonyms:(R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE;1-Benzoyl-(R)-3-methylpiperazine hydrochloride;(R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE , EE 99%;(R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE, 99%, EE 99%;Methanone, [(3R)-3-methyl-1-piperazinyl]phenyl-, hydrochloride (1:1)

Chemical Property of (R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE

Chemical Property:

• PSA: 32.34000
• LogP: 2.18920
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

(R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-1-Benzoyl-3-methylpiperazine hydrochloride is used as pharmaceutical intermediates

Technology Process of (R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE

There total 2 articles about (R)-1-BENZOYL-3-METHYLPIPERAZINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzoyl chloride (98-88-4) → (R)-3-methyl-N-benzoylpiperazine hydrochloride (474010-60-1)

Guidance literature:

(R)-2-methylpiperazine dihydrochloride; With potassium carbonate; In acetonitrile; at 70 ℃; for 18h;

benzoyl chloride; In acetonitrile; at 3 - 20 ℃; for 20.5h;

Reference yield:

→ (R)-3-methyl-N-benzoylpiperazine hydrochloride (474010-60-1)

Guidance literature:

Reference yield: 100.0%

5-bromo-2-thiophenesulfonyl chloride (55854-46-1) + (R)-3-methyl-N-benzoylpiperazine hydrochloride (474010-60-1) → [(R)-4-(5-bromo-thiophene-2-sulfonyl)-3-methyl-piperazin-1-yl]-phenyl-methanone (948990-68-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 45 ℃; for 3h;

upstream raw materials:

benzoyl chloride

Downstream raw materials:

C₂₄H₂₁BrN₆O₃

1-benzoyl-3-(R)-methylpiperazine

(R)-(4-(4-iodophenylsulfonyl)-3-methylpiperazin-1-yl)(phenyl)methanone

[(R)-4-(5-bromo-thiophene-2-sulfonyl)-3-methyl-piperazin-1-yl]-phenyl-methanone