1-[(4-FLUOROPHENYL)SULFONYL]-2-PYRROLIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 1-[(4-FLUOROPHENYL)SULFONYL]-2-PYRROLIDINECARBOXYLIC ACID
• CAS No.: 910481-87-7
• Molecular Formula: C11H12FNO4S
• Molecular Weight: 273.285
• Hs Code.: 2935009090
• Mol file: 910481-87-7.mol

Synonyms:TIMTEC-BB SBB010206;1-(4-FLUORO-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID;1-(4-FLUOROBENZENESULPHONYL)PYRROLIDINE-2-CARBOXYLIC ACID;1-[(4-FLUOROPHENYL)SULFONYL]-2-PYRROLIDINE-2-CARBOXYLIC ACID;1-[(4-FLUOROPHENYL)SULFONYL]-2-PYRROLIDINECARBOXYLIC ACID;AKOS BC-2983;AKOS BBS-00001535;CBI-BB ZERO/006263

Chemical Property of 1-[(4-FLUOROPHENYL)SULFONYL]-2-PYRROLIDINECARBOXYLIC ACID

Chemical Property:

• Melting Point: 96-99°C
• PSA: 83.06000
• LogP: 2.08210

Purity/Quality:

99% ^*data from raw suppliers

1-(4-FLUOROBENZENESULPHONYL)PYRROLIDINE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(4-FLUOROPHENYL)SULFONYL]-2-PYRROLIDINECARBOXYLIC ACID

There total 1 articles about 1-[(4-FLUOROPHENYL)SULFONYL]-2-PYRROLIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

4-Fluorobenzenesulfonyl chloride (349-88-2) + D-Prolin (344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (R)-1-(4-fluorophenylsulfonyl)pyrrolidine-2-carboxylic acid (910481-87-7,251096-96-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm050849w

Reference yield: 81.1%

(R)-1-(4-fluorophenylsulfonyl)pyrrolidine-2-carboxylic acid (910481-87-7,251096-96-5) + (S)-(-)-2-amino-3-phenyl-1-propanol hydrochloride salt → (R)-1-(4-fluorophenylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide (910482-03-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/jm050849w

Reference yield:

(R)-1-(4-fluorophenylsulfonyl)pyrrolidine-2-carboxylic acid (910481-87-7,251096-96-5) → (R)-1-(4-Fluoro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-formyl-2-phenyl-ethyl)-amide

Guidance literature:

Multi-step reaction with 2 steps

1: 81.1 percent / EDC; HOBT; NMM / CH₂Cl₂ / 20 °C

2: 85.7 percent / Dess-Martin reagent / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; 2: Dess-Martin oxidation;

DOI:10.1021/jm050849w

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

D-Prolin

Downstream raw materials:

(R)-1-(4-fluorophenylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

Refernces