3-Thiophenecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)

Base Information

• Chemical Name: 3-Thiophenecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)
• CAS No.: 349662-41-5
• Molecular Formula: C8H11NO3S
• Molecular Weight: 0
• Mol file: 349662-41-5.mol

Synonyms:3-Thiophenecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)

Chemical Property of 3-Thiophenecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)

Chemical Property:

• PSA: 89.79000
• LogP: 1.84450

Purity/Quality:

methyl2-amino-4-(methoxymethyl)thiophene-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Thiophenecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)

There total 1 articles about 3-Thiophenecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

methyl 2-cyanoacetate (105-34-0) + 1-methoxy-3-(((4-methylbenzene)-sulfonyl)-oxy)-2-propanone (349662-38-0) → methyl 2-amino-4-(methoxymethyl)-thiophene-3-carboxylate (349662-41-5)

Guidance literature:

With sodium sulfide; triethylamine; In methanol; at 20 ℃; for 2.5h;

DOI:10.1007/s007060170137

Reference yield: 83.0%

m-phenoxyphenylacetic acid chloride (86750-63-2) + methyl 2-amino-4-(methoxymethyl)-thiophene-3-carboxylate (349662-41-5) → 4-methoxymethyl-2-[2-(3-phenoxyphenyl)acetylamino]-thiophene-3-carboxylic acid methyl ester (877314-45-9)

Guidance literature:

In 1,4-dioxane; at 98 ℃;

DOI:10.1021/jm0503493

Reference yield:

methyl 2-amino-4-(methoxymethyl)-thiophene-3-carboxylate (349662-41-5) → 2-chloro-4-hydroxy-3-methoxymethyl-5-(3-phenoxy-phenyl)-7H-thieno[2,3-b]pyridin-6-one

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / dioxane / 98 °C

2: 61 percent / KN(Si(CH₃)3)2 / tetrahydrofuran / -65 - 10 °C

3: 58 percent / N-chlorosuccinimide / CHCl₃ / Heating

With N-chloro-succinimide; potassium hexamethylsilazane; In tetrahydrofuran; 1,4-dioxane; chloroform;

DOI:10.1021/jm0503493

upstream raw materials:

methyl 2-cyanoacetate

1-methoxy-3-(((4-methylbenzene)-sulfonyl)-oxy)-2-propanone

Downstream raw materials:

4-methoxymethyl-2-[2-(3-phenoxyphenyl)acetylamino]-thiophene-3-carboxylic acid methyl ester

4-hydroxy-3-methoxymethyl-5-(3-phenoxy-phenyl)-7H-thieno[2,3-b]pyridin-6-one

5-chloro-4-methoxymethyl-2-[2-(3-phenoxyphenyl)acetylamino]-thiophene-3-carboxylic acid methyl ester

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