BENZENEETHANIMIDAMIDE,4-BROMO-2-FLUORO-N-HYDROXY

Base Information

• Chemical Name: BENZENEETHANIMIDAMIDE,4-BROMO-2-FLUORO-N-HYDROXY
• CAS No.: 128104-38-1
• Molecular Formula: C8H8BrFN2O
• Molecular Weight: 0
• Mol file: 128104-38-1.mol

Synonyms:BENZENEETHANIMIDAMIDE,4-BROMO-2-FLUORO-N-HYDROXY

Chemical Property of BENZENEETHANIMIDAMIDE,4-BROMO-2-FLUORO-N-HYDROXY

Chemical Property:

• PSA: 58.61000
• LogP: 2.57740

Purity/Quality:

4-BROMO-2-FLUORO-N-HYDROXYBENZENEETHANIMIDAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZENEETHANIMIDAMIDE,4-BROMO-2-FLUORO-N-HYDROXY

There total 2 articles about BENZENEETHANIMIDAMIDE,4-BROMO-2-FLUORO-N-HYDROXY which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(4-bromo-2-fluorophenyl)acetonitrile (114897-91-5) → C8H8BrFN2O (128104-38-1)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; at 20 ℃; for 7h; Reflux;

DOI:10.1021/jm701613h

Reference yield:

(4-bromo-2-fluorophenyl)acetonitrile (114897-91-5) → 2-(4-Bromo-2-fluoro-phenyl)-N-hydroxy-acetamidine (128104-38-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; for 18h; Heating;

DOI:10.1021/jm00085a002

Reference yield: 56.0%

C8H8BrFN2O (128104-38-1) + ethyl chlorocarbonylacetate (36239-09-5) → C13H12BrFN2O3 (1028344-72-0)

Guidance literature:

C₈H₈BrFN₂O; With sodium hydride; In toluene; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

ethyl chlorocarbonylacetate; In toluene; mineral oil; Inert atmosphere; Reflux;

DOI:10.1021/jm701613h

upstream raw materials:

(4-bromo-2-fluorophenyl)acetonitrile

Downstream raw materials:

4-[(4-bromo-2-fluorophenyl)methyl]-3H-1,2,3,5-oxathiadiazole 2-oxide

C₁₃H₁₂BrFN₂O₃

Refernces

• 1、 Ellingboe,Alessi,Dolak,Nguyen,Tomer,Guzzo,Bagli,McCaleb. "Antihyperglycemic activity of novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides". . p. 1176 - 1183. Retrieved 2007/10/02.