(1S,2R)-ethyl 2-((R)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride

Base Information

• Chemical Name: (1S,2R)-ethyl 2-((R)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride
• CAS No.: 1346773-51-0
• Molecular Formula: C17H26ClNO2
• Molecular Weight: 311.84684
• Mol file: 1346773-51-0.mol

Synonyms:(1S,2R)-ethyl 2-((R)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride

Chemical Property of (1S,2R)-ethyl 2-((R)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 4.65200
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

(1S,2R)-Ethyl2-(((R)-1-phenylethyl)amino)cyclohexanecarboxylatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2R)-ethyl 2-((R)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride

There total 10 articles about (1S,2R)-ethyl 2-((R)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate (191986-95-5) → (1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride (1346773-51-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 0 - 20 ℃;

DOI:10.1002/ejoc.200390112

Reference yield:

(R,R,R)-2--1-carbethoxycyclohexane (163877-12-1) → (1R,2R)-2-((R)-1-Phenyl-ethylamino)-cyclohexanecarboxylic acid ethyl ester; hydrochloride (1346773-51-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 0 - 20 ℃;

DOI:10.1002/ejoc.200390112

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → (1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride (1346773-51-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: p-TsOH / benzene / 4 h / Heating

2.1: NaBH₄; isobutyric acid / toluene / 3 h / 0 °C

2.2: HBr / ethyl acetate; propionic acid / 0 °C

2.3: aq. NaHCO₃

3.1: Na / ethanol / 15 h / 80 °C

4.1: HCl / ethyl acetate; dioxane / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium; toluene-4-sulfonic acid; isobutyric Acid; In 1,4-dioxane; ethanol; ethyl acetate; toluene; benzene;

DOI:10.1002/ejoc.200390112

upstream raw materials:

(1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate

(S)-1-phenyl-ethylamine

2-(S-1-phenylethylamino)-cyclohex-1-enecarboxylic acid ethyl ester

ethyl 2-oxocyclohexane carboxylate

Downstream raw materials:

(1S,2S)-2-[(S)-1-phenylethylamino]cyclohexylmethanol

ethyl 2-(((1S,2S)-2-(hydroxymethyl)cyclohexyl)((S)-1-phenylethyl)amino)acetate

ethyl 2-(((1S,2S)-2-((methylsulfonyloxy)methyl)cyclohexyl)((S)-1-phenylethyl)amino)acetate

(2S,3aR,7aS)-ethyl 1-((S)-1-phenylethyl)octahydro-1H-indole-2-carboxylate

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