P7C3-A20

Base Information

Chemical Name:P7C3-A20
CAS No.:1235481-90-9
Molecular Formula:C22H19Br2FN2O
Molecular Weight:506.212
Hs Code.:
Mol file:1235481-90-9.mol

Synonyms:P7C3-A20;3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine;P7C3-A20 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine;P7C3-A20, >=98%

Suppliers and Price of P7C3-A20

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
P7C3-A20 >98%
250 mg
$ 900.00

Crysdot
P7C3-A20 95+%
100mg
$ 922.00

Crysdot
P7C3-A20 95+%
50mg
$ 539.00

Crysdot
P7C3-A20 95+%
25mg
$ 300.00

Cayman Chemical
P7C3-A20 ≥95%
10mg
$ 200.00

Cayman Chemical
P7C3-A20 ≥95%
5mg
$ 119.00

Cayman Chemical
P7C3-A20 ≥95%
25mg
$ 395.00

Cayman Chemical
P7C3-A20 ≥95%
1mg
$ 28.00

Ambeed
P7C3-A20 95+%
250mg
$ 1109.00

Ambeed
P7C3-A20 95+%
1g
$ 1109.00

Total 31 raw suppliers

Chemical Property of P7C3-A20

Chemical Property:

Boiling Point:641.3±55.0 °C(Predicted)
PKA:3.25±0.50(Predicted)
PSA：26.19000
Density:1.57±0.1 g/cm3(Predicted)
LogP:6.85130
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Solubility.:Soluble in DMSO (40 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

P7C3-A20 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description P7C3-A20 is a derivative of P7C3 (Item No. 16682) that has proneurogenic and neuroprotective activity. It increases proliferation in the subgranular zone (SGZ) of the adult mouse dentate gyrus in a dose-dependent manner when administered at doses ranging from 0.1 to 10 μM. It also protects U2OS cells from calcium-induced mitochondrial dissolution. In a rat model of traumatic brain injury, P7C3-A20 (10 mg/kg, i.p., twice daily for one week) decreases contusion volume, increases proliferation in the SGZ, and decreases the latency to reach the platform in the Morris water maze to sham surgery control levels. It also prevents or reverses dopaminergic cell death and motor deficits in a 6-OHDA rat model of Parkinson's disease.

Technology Process of P7C3-A20

There total 10 articles about P7C3-A20 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1260172-05-1
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-N-(3-methoxyphenyl)-4-nitrobenzenesulfonamide

: 1235481-90-9
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline

Guidance literature:: With mercaptoacetic acid; lithium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 313268-18-7
1-(3,6-dibromo-9H-carbazol-9-yl)-3-((3-methoxyphenyl)amino)propan-2-ol

: 1235481-90-9
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline

Guidance literature:: With 4-(trifluoromethyl)morpholine; In dichloromethane;
DOI:10.1016/j.tetlet.2013.06.024

Reference yield:

: 85446-05-5
3,6-dibromo-9-(oxiran-2-ylmethyl)-9H-carbazole

: 1235481-90-9
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; toluene / 0.17 h / -78 °C / Inert atmosphere

1.2: 20 - 100 °C / Inert atmosphere

2.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

3.1: mercaptoacetic acid; lithium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

With n-butyllithium; diethylamino-sulfur trifluoride; mercaptoacetic acid; lithium hydroxide; In hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja108211m