(R)-Isoxazolidin-4-ol Hydrochloride

Base Information

• Chemical Name: (R)-Isoxazolidin-4-ol Hydrochloride
• CAS No.: 338464-48-5
• Molecular Formula: C3H8ClNO2
• Molecular Weight: 125.55412
• Mol file: 338464-48-5.mol

Synonyms:(R)-Isoxazolidin-4-ol Hydrochloride;(R)-isoxazolidin-5-ol

Chemical Property of (R)-Isoxazolidin-4-ol Hydrochloride

Chemical Property:

• PSA: 41.49000
• LogP: 0.01290
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(R)-isoxazolidin-4-olhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-Isoxazolidin-4-ol Hydrochloride

There total 1 articles about (R)-Isoxazolidin-4-ol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N--4-hydroxyisoxazolidine (80041-99-2) → 4-Hydroxytetrahydro-1,2-oxazole hydrochloride (82409-18-5,338464-48-5)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1055/s-1982-29825

Reference yield: 62.0%

(4S)-isoxazolidin-2-ium-4-ol chloride (338464-48-5) + 6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-1-isobutyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid (496791-38-9) → AR-C155858 (496791-37-8)

Guidance literature:

6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-1-isobutyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylic acid; With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 18 - 25 ℃; for 0.5h;

(4S)-isoxazolidin-2-ium-4-ol chloride; In dichloromethane; at 18 - 25 ℃; for 3h;

DOI:10.1021/jm060995h

upstream raw materials:

N--4-hydroxyisoxazolidine

Downstream raw materials:

AR-C155858

Refernces

• 1、 Amlaiky,Leclerc. "Synthesis of the new heterocyclic hydroxy compounds 4-hydroxyisoxazolidine, 3-hydroxymethylisoxazolidine, 3-hydroxymethylhexahydro-1,2-oxazine,and 4-hydroxyhexahydro-1,2-oxazepine". . p. 426 - 428. Retrieved 2007/10/02.