Technology Process of 11,12-CIS-13,14-DIHYDRORETINOL
There total 4 articles about 11,12-CIS-13,14-DIHYDRORETINOL which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 3-formylbutyrate; 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide;
With
18-crown-6 ether; potassium tert-butylate;
In
dichloromethane;
at -78 - 20 ℃;
for 12h;
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 ℃;
for 0.5h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C
2.1: 18-crown-6 ether; potassium tert-butylate / dichloromethane / 12 h / -78 - 20 °C
2.2: 0.5 h / 0 °C
With
18-crown-6 ether; potassium tert-butylate; hydrogen;
palladium 10% on activated carbon;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 24 h / 20 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C
2.2: 24 h / 20 °C
3.1: 18-crown-6 ether; potassium tert-butylate / dichloromethane / 12 h / -78 - 20 °C
3.2: 0.5 h / 0 °C
With
lithium aluminium tetrahydride; 18-crown-6 ether; potassium tert-butylate;
sodium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
