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62285-98-7

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  • High quality [5-(4-Methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienyl] supplier in China

    Cas No: 62285-98-7

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  • ((2E,4E)-3-METHYL-5-(2,6,6-TRIMETHYLCYCLOHEX-2-EN-1-YL)PENTA-2,4-DIEN-1-YL)TRIPHENYLPHOSPHONIUM BROMIDE CAS NO.62285-98-7

    Cas No: 62285-98-7

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  • [(2E,4E)-3-Methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl]-triphenylphosphonium bromide

    Cas No: 62285-98-7

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62285-98-7 Usage

Uses

[(2E,4E)-3-Methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadien-1-yl]triphenyl-phosphonium Bromide is used in the synthesis of all-trans-retinoic acid (ATRA), a precursor of vitamin A

Check Digit Verification of cas no

The CAS Registry Mumber 62285-98-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,2,8 and 5 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 62285-98:
(7*6)+(6*2)+(5*2)+(4*8)+(3*5)+(2*9)+(1*8)=137
137 % 10 = 7
So 62285-98-7 is a valid CAS Registry Number.
InChI:InChI=1S/C33H38P.BrH/c1-27(22-23-32-28(2)15-14-25-33(32,3)4)24-26-34(29-16-8-5-9-17-29,30-18-10-6-11-19-30)31-20-12-7-13-21-31;/h5-13,15-24,32H,14,25-26H2,1-4H3;1H/q+1;/p-1/b23-22+,27-24+;

62285-98-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [3-Methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl]triphenylphosphonium bromide

1.2 Other means of identification

Product number -
Other names [3-methyl-5-(2,6,6-trimethylcyclohexene-1-yl)-2E,4E-pentadiene]triphenyl phosphonium bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:62285-98-7 SDS

62285-98-7Synthetic route

(1E)-1-(2,6,6-trimethylcyclohex-1-enyl)-3-methyl-1,4-pentadien-3-ol
59057-30-6

(1E)-1-(2,6,6-trimethylcyclohex-1-enyl)-3-methyl-1,4-pentadien-3-ol

triphenylphosphine hydrobromide
6399-81-1

triphenylphosphine hydrobromide

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
In methanol for 75h; Ambient temperature;100%
In methanol at 20℃; for 20h;73%
In tetrahydrofuran
3-methyl-5-bromo-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-pentadiene
38987-92-7

3-methyl-5-bromo-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-pentadiene

triphenylphosphine
603-35-0

triphenylphosphine

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
In acetonitrile at 50 - 55℃; for 5h; Inert atmosphere;92.8%
In acetonitrile at 50 - 55℃; for 5h; Inert atmosphere;92.1%
(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexenyl)-2,4-pentadien-1-ol
3917-39-3

(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexenyl)-2,4-pentadien-1-ol

triphenylphosphine hydrobromide
6399-81-1

triphenylphosphine hydrobromide

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
In methanol for 17h; Ambient temperature;
triphenylphosphine hydrobromide
6399-81-1

triphenylphosphine hydrobromide

Acetic acid (2Z,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienyl ester

Acetic acid (2Z,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienyl ester

A

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

B

β-ionylidenetriphenylphosphonium bromide

β-ionylidenetriphenylphosphonium bromide

Conditions
ConditionsYield
Stage #1: Acetic acid (2Z,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienyl ester With lithium aluminium tetrahydride
Stage #2: triphenylphosphine hydrobromide
(E)-β-ionone
79-77-6

(E)-β-ionone

vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

triphenylphosphine hydrobromide
6399-81-1

triphenylphosphine hydrobromide

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Stage #1: (E)-β-ionone; vinyl magnesium bromide
Stage #2: triphenylphosphine hydrobromide Further stages.;
(E)-β-ionone
79-77-6

(E)-β-ionone

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / tetrahydrofuran / 20 h / 20 °C
2: 73 percent / methanol / 20 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 94 percent / tetrahydrofuran / 14 h / Ambient temperature
2: 100 percent / methanol / 75 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 24 h / 20 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C
2.2: 24 h / 20 °C
View Scheme
(2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoate
17974-55-9

(2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoate

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / diethyl ether / 0.25 h / Ambient temperature
2: methanol / 17 h / Ambient temperature
View Scheme
[5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methyl-2-penten-4-ynyl]triphenylphosphonium bromide

[5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methyl-2-penten-4-ynyl]triphenylphosphonium bromide

2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol
5244-34-8

2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol

nickel
7440-02-0

nickel

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
In methanol; dichloromethane; ethyl acetate
(2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoate
17974-55-9

(2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoate

triphenylphosphine hydrobromide
6399-81-1

triphenylphosphine hydrobromide

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Stage #1: (2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoate With lithium aluminium tetrahydride In diethyl ether at 0℃; for 0.5h;
Stage #2: triphenylphosphine hydrobromide In methanol at 20℃; for 24h;
2-(bromomethyl)-1,3,3-trimethylcyclohex-1-ene
59633-88-4

2-(bromomethyl)-1,3,3-trimethylcyclohex-1-ene

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hexane / 4 h / 50 - 55 °C / Inert atmosphere
2.1: potassium hydroxide / isopropyl alcohol / 1 h / -5 - 5 °C / Inert atmosphere
3.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
3.2: 3 h / 20 - 25 °C
4.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
C28H32P(1+)*Cl(1-)

C28H32P(1+)*Cl(1-)

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium ethanolate / N,N-dimethyl-formamide / 5 h / -5 - 10 °C / Inert atmosphere
2.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
2.2: 3 h / 20 - 25 °C
3.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
diethyl [(2,2,6-trimethylcyclohexyl)methyl]phosphonate

diethyl [(2,2,6-trimethylcyclohexyl)methyl]phosphonate

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium methylate / N,N-dimethyl-formamide / 1 h / 0 - 15 °C / Inert atmosphere
2.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
2.2: 3 h / 20 - 25 °C
3.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
triphenyl((2,6,6-trimethylcyclohex-1-enyl)methyl)phosphonium bromide
56013-01-5

triphenyl((2,6,6-trimethylcyclohex-1-enyl)methyl)phosphonium bromide

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium hydroxide / isopropyl alcohol / 1 h / -5 - 5 °C / Inert atmosphere
2.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
2.2: 3 h / 20 - 25 °C
3.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
3-methyl-5-acetoxy-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-pentadiene
3917-38-2

3-methyl-5-acetoxy-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-pentadiene

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
1.2: 3 h / 20 - 25 °C
2.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
3,7-dimethylocta-1,6-dien-3-ol
78-70-6

3,7-dimethylocta-1,6-dien-3-ol

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogen bromide; sodium hydroxide / water; dichloromethane / 2 h / 30 - 35 °C / Inert atmosphere
1.2: 2 h / 35 - 40 °C
2.1: hexane / 4 h / 50 - 55 °C / Inert atmosphere
3.1: potassium hydroxide / isopropyl alcohol / 1 h / -5 - 5 °C / Inert atmosphere
4.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
4.2: 3 h / 20 - 25 °C
5.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydroxide; thionyl chloride / 1,2-dichloro-ethane; water / 3 h / 40 - 45 °C
1.2: 5 h / 70 - 75 °C
2.1: acetonitrile / 4 h / 60 - 65 °C / Inert atmosphere
3.1: sodium ethanolate / N,N-dimethyl-formamide / 5 h / -5 - 10 °C / Inert atmosphere
4.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
4.2: 3 h / 20 - 25 °C
5.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydroxide; thionyl chloride / 1,2-dichloro-ethane; water / 3 h / 40 - 45 °C
1.2: 5 h / 70 - 75 °C
2.1: 4 h / 105 - 110 °C / Inert atmosphere
3.1: sodium methylate / N,N-dimethyl-formamide / 1 h / 0 - 15 °C / Inert atmosphere
4.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
4.2: 3 h / 20 - 25 °C
5.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
1,3,3-trimethyl-2-chloromethylcyclohexene

1,3,3-trimethyl-2-chloromethylcyclohexene

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetonitrile / 4 h / 60 - 65 °C / Inert atmosphere
2.1: sodium ethanolate / N,N-dimethyl-formamide / 5 h / -5 - 10 °C / Inert atmosphere
3.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
3.2: 3 h / 20 - 25 °C
4.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: 4 h / 105 - 110 °C / Inert atmosphere
2.1: sodium methylate / N,N-dimethyl-formamide / 1 h / 0 - 15 °C / Inert atmosphere
3.1: sodium hydroxide / water; dichloromethane / 3 h / 15 - 20 °C
3.2: 3 h / 20 - 25 °C
4.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
4-bromo-3-methyl-2-buten-1-ol acetate
32659-14-6

4-bromo-3-methyl-2-buten-1-ol acetate

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetonitrile / 4 h / 60 - 65 °C / Inert atmosphere
2.1: sodium ethanolate / N,N-dimethyl-formamide / 2 h / 0 - 5 °C / Inert atmosphere
3.1: sodium hydroxide / dichloromethane; water / 3 h / 15 - 20 °C
3.2: 3 h / 20 - 25 °C
4.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: methanol / 4 h / 100 - 105 °C / Inert atmosphere
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / -10 - 0 °C / Inert atmosphere
3.1: sodium hydroxide / dichloromethane; water / 3 h / 15 - 20 °C
3.2: 3 h / 20 - 25 °C
4.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: ethanol / 4 h / 105 - 110 °C / Inert atmosphere
2.1: sodium ethanolate / toluene / 2 h / -5 - 5 °C / Inert atmosphere
3.1: sodium hydroxide / dichloromethane; water / 3 h / 15 - 20 °C
3.2: 3 h / 20 - 25 °C
4.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
C25H26O2P(1+)*Br(1-)

C25H26O2P(1+)*Br(1-)

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium ethanolate / N,N-dimethyl-formamide / 2 h / 0 - 5 °C / Inert atmosphere
2.1: sodium hydroxide / dichloromethane; water / 3 h / 15 - 20 °C
2.2: 3 h / 20 - 25 °C
3.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
C25H26O2P(1+)*Cl(1-)

C25H26O2P(1+)*Cl(1-)

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium methylate / N,N-dimethyl-formamide / 2 h / 5 - 10 °C / Inert atmosphere
2.1: sodium hydroxide / dichloromethane; water / 3 h / 15 - 20 °C
2.2: 3 h / 20 - 25 °C
3.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
diethyl 2-methyl-4-acetoxy-2-butenylphosphonate

diethyl 2-methyl-4-acetoxy-2-butenylphosphonate

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium ethanolate / toluene / 2 h / -5 - 5 °C / Inert atmosphere
2.1: sodium hydroxide / dichloromethane; water / 3 h / 15 - 20 °C
2.2: 3 h / 20 - 25 °C
3.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
dimethyl 2-methyl-4-acetoxy-2-butenylphosphonate

dimethyl 2-methyl-4-acetoxy-2-butenylphosphonate

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / -10 - 0 °C / Inert atmosphere
2.1: sodium hydroxide / dichloromethane; water / 3 h / 15 - 20 °C
2.2: 3 h / 20 - 25 °C
3.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
(E)-1-O-acetyl-4-chloro-3-methyl-2-buten-1-ol
24529-80-4

(E)-1-O-acetyl-4-chloro-3-methyl-2-buten-1-ol

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetonitrile / 4 h / 70 - 75 °C / Inert atmosphere
2.1: sodium methylate / N,N-dimethyl-formamide / 2 h / 5 - 10 °C / Inert atmosphere
3.1: sodium hydroxide / dichloromethane; water / 3 h / 15 - 20 °C
3.2: 3 h / 20 - 25 °C
4.1: acetonitrile / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
4-palmitoyloxy-2-methyl-2-buten-1-al

4-palmitoyloxy-2-methyl-2-buten-1-al

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

retinyl palmitate
79-81-2

retinyl palmitate

Conditions
ConditionsYield
With sodium ethanolate In N,N-dimethyl-formamide at -5 - 5℃; for 3h; Wittig Olefination; Inert atmosphere;91.3%
(E)-4-acetoxy-2-methylcrotonaldehyde
26586-02-7

(E)-4-acetoxy-2-methylcrotonaldehyde

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Retinol acetate
127-47-9

Retinol acetate

Conditions
ConditionsYield
With sodium ethanolate In N,N-dimethyl-formamide at -5 - 0℃; for 2h; Solvent; Temperature; Reagent/catalyst; Wittig Olefination; Inert atmosphere;91%
With sodium ethanolate In N,N-dimethyl-formamide at -5 - 5℃; for 2h; Time; Inert atmosphere;90.7%
(Z)-3-methyl-4-oxobut-2-enoic acid
70143-04-3

(Z)-3-methyl-4-oxobut-2-enoic acid

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Stage #1: (Z)-3-methyl-4-oxobut-2-enoic acid; 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide With sodium hydroxide In isopropyl alcohol at 20 - 30℃; for 3h; Wittig Olefination; Inert atmosphere;
Stage #2: With hydrogenchloride; palladium diacetate In isopropyl alcohol at 60℃; pH=7 - 8;
86.3%
Stage #1: (Z)-3-methyl-4-oxobut-2-enoic acid; 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide With sodium hydroxide In isopropyl alcohol at 20 - 30℃; for 3h; Wittig Olefination; Inert atmosphere;
Stage #2: With hydrogenchloride; palladium diacetate In isopropyl alcohol at 60℃; pH=7-8; Inert atmosphere;
86.3%
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

4-formyl-2-[3-oxo-2-methyl-(1E)-propenyl]pyridine
188554-16-7

4-formyl-2-[3-oxo-2-methyl-(1E)-propenyl]pyridine

2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine
188554-17-8

2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine

Conditions
ConditionsYield
With sodium ethanolate In ethanol76%
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

(Z)-3-Iodo-4-oxo-but-2-enoic acid ethyl ester
174836-86-3

(Z)-3-Iodo-4-oxo-but-2-enoic acid ethyl ester

(2Z,4E,6E,8E)-3-Iodo-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid ethyl ester
743421-41-2

(2Z,4E,6E,8E)-3-Iodo-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (Z)-3-Iodo-4-oxo-but-2-enoic acid ethyl ester With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide
Stage #2: 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide Further stages.;
74%
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

bis(3-formyl-3-methyl-2-propenyl) sulfide
251291-80-2

bis(3-formyl-3-methyl-2-propenyl) sulfide

retinyl sulfide
268728-47-8

retinyl sulfide

Conditions
ConditionsYield
Stage #1: 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide; bis(3-formyl-3-methyl-2-propenyl) sulfide In DMF (N,N-dimethyl-formamide) at -20℃;
Stage #2: With sodium methylate In DMF (N,N-dimethyl-formamide) at -20 - 20℃; for 3.5h;
68%
4-t-butyldimethylsilyloxy-2-butynal
75859-97-1

4-t-butyldimethylsilyloxy-2-butynal

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

tert-Butyl-dimethyl-[(4Z,6E,8E)-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-4,6,8-trien-2-ynyloxy]-silane
75867-37-7

tert-Butyl-dimethyl-[(4Z,6E,8E)-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-4,6,8-trien-2-ynyloxy]-silane

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran for 3h; Ambient temperature;52%
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

2-methyl-3-[3-(1-methyl-2-oxoethylidene)-cyclohex-1-enyl]-propenal
454442-05-8

2-methyl-3-[3-(1-methyl-2-oxoethylidene)-cyclohex-1-enyl]-propenal

C43H60

C43H60

Conditions
ConditionsYield
With sodium methylate In methanol for 1h;40%
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

13-[(4R)-4-(β-D-glucopyranosyloxy)-2,6,6-trimethylcyclohex-1-enyl]-2,7,11-trimethyltrideca-2,4,6,8,10,12-hexaenal

13-[(4R)-4-(β-D-glucopyranosyloxy)-2,6,6-trimethylcyclohex-1-enyl]-2,7,11-trimethyltrideca-2,4,6,8,10,12-hexaenal

A

(all-E)-(3R)-3-(β-D-glucopyranosyloxy)-β,β-carotene
135589-15-0

(all-E)-(3R)-3-(β-D-glucopyranosyloxy)-β,β-carotene

B

(9'Z)-(3R)-3-(β-D-glucopyranosyloxy)-β,β-carotene

(9'Z)-(3R)-3-(β-D-glucopyranosyloxy)-β,β-carotene

Conditions
ConditionsYield
Stage #1: 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide; 13-[(4R)-4-(β-D-glucopyranosyloxy)-2,6,6-trimethylcyclohex-1-enyl]-2,7,11-trimethyltrideca-2,4,6,8,10,12-hexaenal With sodium methylate In methanol; dichloromethane at 20℃; for 3h; Wittig condensation;
Stage #2: With Dowex 50W-X8 (H+) In methanol; dichloromethane at 20℃; for 0.333333h;
A 28%
B 10%
(2E,4E,6E,8E,10E,12E,14E)-2,7,11,15,19-pentamethylicosa-2,4,6,8,10,12,14,18-octaenal
103956-99-6, 1071-52-9

(2E,4E,6E,8E,10E,12E,14E)-2,7,11,15,19-pentamethylicosa-2,4,6,8,10,12,14,18-octaenal

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

trans-gamma-Carotene
472-93-5

trans-gamma-Carotene

Conditions
ConditionsYield
With sodium methylate In methanol; N,N-dimethyl-formamide
2-Methyl-4-(thioacetyl)-2-(E)-butenal
72053-20-4

2-Methyl-4-(thioacetyl)-2-(E)-butenal

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

11-cis-Retinylthioacetat
72053-19-1, 72075-18-4

11-cis-Retinylthioacetat

Conditions
ConditionsYield
(i) nBuLi, (ii) /BRN= 2075468/; Multistep reaction;
2-Methyl-4-(thioacetyl)-2-(E)-butenal
72053-20-4

2-Methyl-4-(thioacetyl)-2-(E)-butenal

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

11-trans-Retinylthioacetat
72053-19-1, 72075-18-4

11-trans-Retinylthioacetat

Conditions
ConditionsYield
(i) nBuLi, (ii) /BRN= 2075468/; Multistep reaction;
acetic acid trans-4-oxo-but-2-enyl ester
38982-39-7

acetic acid trans-4-oxo-but-2-enyl ester

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

Acetic acid (2E,4E,6E,8E)-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester

Acetic acid (2E,4E,6E,8E)-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane 1.) 1 h, -60 deg C; 2.) 2 h to RT; Yield given;
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

ethyl trans-13,14-dihydro-13-desmethyl-13,14-methyleneretinoate
89887-40-1

ethyl trans-13,14-dihydro-13-desmethyl-13,14-methyleneretinoate

ethyl cis-13,14-dihydro-13-desmethyl-13,14-methyleneretinoate
89827-99-6

ethyl cis-13,14-dihydro-13-desmethyl-13,14-methyleneretinoate

Conditions
ConditionsYield
With potassium tert-butylate benzene, 1) 15 min 2) 8h, r.t.; Yield given. Multistep reaction. Yields of byproduct given;
1-Carbethoxy-2-formyl-2-methyl-cyclopropan
20417-63-4

1-Carbethoxy-2-formyl-2-methyl-cyclopropan

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

ethyl trans-13,14-dihydro-13,14-methyleneretinoate
89887-37-6

ethyl trans-13,14-dihydro-13,14-methyleneretinoate

ethyl cis-13,14-dihydro-13,14-methyleneretinoate
89827-98-5

ethyl cis-13,14-dihydro-13,14-methyleneretinoate

Conditions
ConditionsYield
With potassium tert-butylate benzene, 1) 15 min 2) 22h, r.t.; Yield given. Multistep reaction. Yields of byproduct given;
4,4-dimethoxy-3-methyl-but-2-en-1-al
62285-97-6

4,4-dimethoxy-3-methyl-but-2-en-1-al

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

2-((1E,3E,5E,7E)-9,9-Dimethoxy-3,8-dimethyl-nona-1,3,5,7-tetraenyl)-1,3,3-trimethyl-cyclohexene

2-((1E,3E,5E,7E)-9,9-Dimethoxy-3,8-dimethyl-nona-1,3,5,7-tetraenyl)-1,3,3-trimethyl-cyclohexene

Conditions
ConditionsYield
With sodium ethanolate In ethanol; dichloromethane at 0℃; for 1h;
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

4-(tert-butyldimethylsilyloxy)-2-methylbutanal
115797-15-4

4-(tert-butyldimethylsilyloxy)-2-methylbutanal

13,14-dihydro-all-trans retinol
115797-14-3

13,14-dihydro-all-trans retinol

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride 1.) Wittig-reaction; Multistep reaction;
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienylidenetriphenylphosphorane
71987-74-1

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienylidenetriphenylphosphorane

Conditions
ConditionsYield
With phenyllithium In diethyl ether for 0.0833333h; Ambient temperature;
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

(2E,4E,6E,8E,10E)-2,7,11-trimethyl-12-oxotrideca-2,4,6,8,10-pentaenal
160456-53-1

(2E,4E,6E,8E,10E)-2,7,11-trimethyl-12-oxotrideca-2,4,6,8,10-pentaenal

(all-E)-sintaxanthin
4586-97-4

(all-E)-sintaxanthin

Conditions
ConditionsYield
With sodium hydride In dichloromethane at 20℃; for 48h; Yield given;
(2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial
5056-17-7

(2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

12'-apo-β-caroten-12'-al
1638-05-7

12'-apo-β-caroten-12'-al

Conditions
ConditionsYield
With sodium hydride In dichloromethane at 20℃; for 64h; Yield given;
With sodium methylate In methanol at 0℃; for 0.5h; Wittig olefination;
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

4-formyl-2-[3-oxo-2-methyl-(1E)-propenyl]pyridine
188554-16-7

4-formyl-2-[3-oxo-2-methyl-(1E)-propenyl]pyridine

A

2-[(1E,3Z,5E,7E)-2,4-Dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-1,3,5,7-tetraenyl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-pyridine

2-[(1E,3Z,5E,7E)-2,4-Dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-1,3,5,7-tetraenyl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-pyridine

B

2-[(1E,3Z,5E,7E)-2,6-Dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-1,3,5,7-tetraenyl]-4-[(1Z,3E,5E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-pyridine

2-[(1E,3Z,5E,7E)-2,6-Dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-1,3,5,7-tetraenyl]-4-[(1Z,3E,5E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-pyridine

C

2-[(1E,3E,5E,7E)-2,6-Dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-1,3,5,7-tetraenyl]-4-[(1Z,3E,5E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-pyridine

2-[(1E,3E,5E,7E)-2,6-Dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-1,3,5,7-tetraenyl]-4-[(1Z,3E,5E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-pyridine

D

2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine
188554-17-8

2-[(1E,3E,5E,7E)-2,6-dimethyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-1,3,5,7-tetraen-1-yl]-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl]pyridine

Conditions
ConditionsYield
With sodium ethanolate 1.) EtOH, room temp., 2.) CH3NO2, reflux; Yield given. Multistep reaction;
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

(2E)-4-[(tert-butyldiphenylsilyl)oxy]-2-fluorobut-2-enal
186953-22-0

(2E)-4-[(tert-butyldiphenylsilyl)oxy]-2-fluorobut-2-enal

(7E,9E,13E)-tert-butyldiphenylsilyl 13-demethyl-13-fluororetinyl ether
186953-39-9

(7E,9E,13E)-tert-butyldiphenylsilyl 13-demethyl-13-fluororetinyl ether

Conditions
ConditionsYield
With n-butyllithium 1.) THF, hexane, -78 deg C, 2.) THF, hexane, 25 deg C, 5 h; Yield given. Multistep reaction;
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

(Z)-1-(tert-butyldimethylsilyloxy)-3-iodo-3-methylprop-2-ene
148802-00-0

(Z)-1-(tert-butyldimethylsilyloxy)-3-iodo-3-methylprop-2-ene

A

tert-butyldimethylsilyl Δ13-(Z)-retinyl ether
118304-54-4

tert-butyldimethylsilyl Δ13-(Z)-retinyl ether

B

tert-Butyl-[(2Z,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyloxy]-dimethyl-silane
118304-54-4, 118353-70-1

tert-Butyl-[(2Z,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyloxy]-dimethyl-silane

Conditions
ConditionsYield
With potassium tert-butylate; tert.-butyl lithium In diethyl ether; pentane at -75 - 25℃; for 6h; Wittig reaction;
4,4'-diapo-ψ,ψ-carotene-4,4'-dial
13920-19-9, 5056-18-8

4,4'-diapo-ψ,ψ-carotene-4,4'-dial

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

3,7,11,15,20,24,28,32-octamethyl-1,34-bis(2,6,6-trimethylcyclohex-1-enyl)tetratriaconta-1,3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33-heptadecaene
24513-48-2

3,7,11,15,20,24,28,32-octamethyl-1,34-bis(2,6,6-trimethylcyclohex-1-enyl)tetratriaconta-1,3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33-heptadecaene

Conditions
ConditionsYield
With sodium hydride In dichloromethane Wittig reaction;67 % Spectr.
6,6'-diapocarotene-6,6'-dial
34561-05-2

6,6'-diapocarotene-6,6'-dial

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

3,9,13,18,22,28-hexamethyl-1,30-bis(2,6,6-trimethylcyclohex-1-enyl)triaconta-1,3,5,7,9,11,13,15,17,19,21,23,25,27,29-pentadecaene

3,9,13,18,22,28-hexamethyl-1,30-bis(2,6,6-trimethylcyclohex-1-enyl)triaconta-1,3,5,7,9,11,13,15,17,19,21,23,25,27,29-pentadecaene

Conditions
ConditionsYield
With sodium hydride In dichloromethane Wittig reaction;66 % Spectr.

62285-98-7Relevant articles and documents

Preparation method of vitamin A acetate intermediate C15 and vitamin A acetate

-

, (2020/08/18)

The invention provides a preparation method of a vitamin A acetate intermediate C15 and vitamin A acetate. The method comprises the following steps: taking 1-halogenated-2-methyl-4-acetoxy-2-butene asa raw material, preparing a corresponding Wittig reagent through a substitution reaction with triphenylphosphine or triester phosphite, then carrying out a Wittig reaction with beta-cyclocitral, hydrolyzing an ester group under an alkaline condition, acidifying to obtain a corresponding halide, and carrying out a substitution reaction with triphenylphosphine or triester phosphite again to prepareC15. The vitamin A acetate can be prepared by carrying out a Wittig reaction on the obtained C15 and 2-methyl-4-acetoxy-2-butenal under an alkaline condition. The method has the advantages of singlereaction type, easy operation and realization of reaction conditions, safe and environment-friendly operation, simple post-treatment and low cost; and the reaction activity is strong, the reaction selectivity is high, the atom economy is high, and the target product yield and purity are high.

All-Trans-Retinol: All-Trans-13,14-Dihydroretinol Saturase and Methods of Its Use

-

Page/Page column 2; 19; 22; Sheet 22/24, (2008/12/08)

Compositions of all-trans-retinol: all-trans-13,14-dihydroretinal saturase and methods of use thereof are provided.

Synthesis of iodinated analogues of all trans retinoic acid (ATRA) for SPECT imaging

Li, Haibing,Morin, Christophe

, p. 5673 - 5676 (2007/10/03)

Two derivatives of all trans retinoic acid in which one of the methyl groups has been replaced by iodine have been prepared.

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