62285-98-7Relevant articles and documents
Preparation method of vitamin A acetate intermediate C15 and vitamin A acetate
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, (2020/08/18)
The invention provides a preparation method of a vitamin A acetate intermediate C15 and vitamin A acetate. The method comprises the following steps: taking 1-halogenated-2-methyl-4-acetoxy-2-butene asa raw material, preparing a corresponding Wittig reagent through a substitution reaction with triphenylphosphine or triester phosphite, then carrying out a Wittig reaction with beta-cyclocitral, hydrolyzing an ester group under an alkaline condition, acidifying to obtain a corresponding halide, and carrying out a substitution reaction with triphenylphosphine or triester phosphite again to prepareC15. The vitamin A acetate can be prepared by carrying out a Wittig reaction on the obtained C15 and 2-methyl-4-acetoxy-2-butenal under an alkaline condition. The method has the advantages of singlereaction type, easy operation and realization of reaction conditions, safe and environment-friendly operation, simple post-treatment and low cost; and the reaction activity is strong, the reaction selectivity is high, the atom economy is high, and the target product yield and purity are high.
All-Trans-Retinol: All-Trans-13,14-Dihydroretinol Saturase and Methods of Its Use
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Page/Page column 2; 19; 22; Sheet 22/24, (2008/12/08)
Compositions of all-trans-retinol: all-trans-13,14-dihydroretinal saturase and methods of use thereof are provided.
Synthesis of iodinated analogues of all trans retinoic acid (ATRA) for SPECT imaging
Li, Haibing,Morin, Christophe
, p. 5673 - 5676 (2007/10/03)
Two derivatives of all trans retinoic acid in which one of the methyl groups has been replaced by iodine have been prepared.