2-(2,3-Dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(2,3-Dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 445303-13-9
• Molecular Formula: C15H21BO2
• Molecular Weight: 244.142
• Hs Code.: 2934999090
• Mol file: 445303-13-9.mol

Synonyms:2-(2,3-Dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2,3-Dihydro-1H-inden-5-boronic acid, pinacol ester

Chemical Property of 2-(2,3-Dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• PSA: 18.46000
• LogP: 2.47450
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dihydro-1H-inden-5-boronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-(2,3-Dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 6 articles about 2-(2,3-Dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 2-(2,3-dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (445303-13-9) + 2,3-dihydro-1H-inden-5-yl trifluoromethanesulfonate (143287-97-2)

Guidance literature:

Reference yield: 83.0%

5-bromoindane (6134-54-9) + bis(pinacol)diborane (73183-34-3) → 2-(2,3-dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (445303-13-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

Reference yield: 74.0%

(E)-1-(2,3-dihydro-1H-inden-5-yl)ethan-1-one O-perfluorobenzoyl oxime + bis(pinacol)diborane (73183-34-3) → 2-(2,3-dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (445303-13-9)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; 2-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; tris<3,5-bis(trifluoromethyl)phenyl>phosphane; palladium dichloride; In 1,2-dichloro-ethane; at 120 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202006740

upstream raw materials:

5-bromoindane

bis(pinacol)diborane

indan-5-amine

Downstream raw materials:

(2S,3R,4R,5S,6R)-2-(4-chloro-3-((2,3-dihydro-1H-inden-5-yl)methyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

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