4-(BroMoMethyl)-2-fluoro-1-iodobenzene

Base Information

• Chemical Name: 4-(BroMoMethyl)-2-fluoro-1-iodobenzene
• CAS No.: 1022931-83-4
• Molecular Formula: C7H5BrFI
• Molecular Weight: 314.924
• Hs Code.: 2903998090
• Mol file: 1022931-83-4.mol

Synonyms:4-(BroMoMethyl)-2-fluoro-1-iodobenzene;3-Fluoro-4-iodobenzyl bromide;4-(Bromomethyl)-2-fluoro-1-iodobenzene, alpha-Bromo-3-fluoro-4-iodotoluene

Chemical Property of 4-(BroMoMethyl)-2-fluoro-1-iodobenzene

Chemical Property:

• PSA: 0.00000
• LogP: 3.32520

Purity/Quality:

95% ^*data from raw suppliers

3-Fluoro-4-iodobenzylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(BroMoMethyl)-2-fluoro-1-iodobenzene

There total 1 articles about 4-(BroMoMethyl)-2-fluoro-1-iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2‐fluoro‐1‐iodo‐4‐methylbenzene (452-79-9) → 4-(bromomethyl)-2-fluoro-1-iodobenzene (1022931-83-4)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 20h; Heating / reflux;

Reference yield: 62.0%

4-(bromomethyl)-2-fluoro-1-iodobenzene (1022931-83-4) + (6R)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether (207923-14-6) → (2S,5R)-2-[(3-fluoro-4-iodophenyl)methyl]-3,6-dimethoxy-2-methyl-5-(propan-2-yl)-2,5-dihydropyrazine

Guidance literature:

(6R)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-(bromomethyl)-2-fluoro-1-iodobenzene; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3h;

DOI:10.1016/j.jfluchem.2015.07.015

Reference yield: 56.0%

4-(bromomethyl)-2-fluoro-1-iodobenzene (1022931-83-4) + (6S)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether (914399-92-1) → (2R,5S)-2-[(3-fluoro-4-iodophenyl)methyl]-3,6-dimethoxy-2-methyl-5-(propan-2-yl)-2,5-dihydropyrazine

Guidance literature:

(6S)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-(bromomethyl)-2-fluoro-1-iodobenzene; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3h;

DOI:10.1016/j.jfluchem.2015.07.015

upstream raw materials:

2‐fluoro‐1‐iodo‐4‐methylbenzene

Downstream raw materials:

1-[(3-fluoro-4-iodophenyl)methyl]-2-pyrrolidinone

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