Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate

Base Information

Chemical Name:Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate
CAS No.:214962-40-0
Molecular Formula:C28H40N4O8S2
Molecular Weight:624.7692
Hs Code.:
Mol file:214962-40-0.mol

Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate

Synonyms:Ibutamoren mesylate;L 163191;Mk 0677;Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate;Ibutamoren Mesylate,MK-0677

Suppliers and Price of Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
MK 0677
10mg
$ 409.00

Tocris
MK0677 ≥98%(HPLC)
10
$ 171.00

Tocris
MK0677 ≥98%(HPLC)
50
$ 717.00

Biorbyt Ltd
Ibutamoren Mesylate(MK-0677) >98%
250 mg
$ 615.40

Biorbyt Ltd
Ibutamoren Mesylate(MK-0677) >98%
100 mg
$ 414.80

Total 1 raw suppliers

Chemical Property of Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate

Chemical Property:

Purity/Quality:: MK 0677 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate

There total 33 articles about Propanamide, 2-amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methyl-, (R)-, monomethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 498-94-2
isonipecotic acid

: 191487-52-2,214962-40-0,159752-10-0
MK-677

Guidance literature:: Multi-step reaction with 12 steps

1: 97 percent / K₂CO₃ / H₂O / 58 h / 22 °C

2: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C

3: 94 percent / H₂, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr

4: 99 percent / TFA / CH₂Cl₂ / 17 h / 35 °C

5: NaBH₄ / toluene / 0.5 h / -2 °C

6: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C

7: 93 percent / H₂ / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr

8: DCC, HOBt / H₂O; various solvent(s) / 5 h / Ambient temperature

9: MsOH / ethanol / 7.5 h / 35 - 40 °C

10: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature

11: MsOH / ethanol / 35 - 40 °C

12: ethanol; ethyl acetate / 55 °C

With sodium tetrahydroborate; oxalyl dichloride; methanesulfonic acid; methyl-phenyl-thioether; hydrogen; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(97)00359-1

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 191487-52-2,214962-40-0,159752-10-0
MK-677

Guidance literature:: Multi-step reaction with 9 steps

1: 99 percent / TFA / CH₂Cl₂ / 17 h / 35 °C

2: NaBH₄ / toluene / 0.5 h / -2 °C

3: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C

4: 93 percent / H₂ / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr

5: DCC, HOBt / H₂O; various solvent(s) / 5 h / Ambient temperature

6: MsOH / ethanol / 7.5 h / 35 - 40 °C

7: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature

8: MsOH / ethanol / 35 - 40 °C

9: ethanol; ethyl acetate / 55 °C

With sodium tetrahydroborate; methanesulfonic acid; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/S0040-4020(97)00359-1

Reference yield:

: 167484-18-6
benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate

: 191487-52-2,214962-40-0,159752-10-0
MK-677

Guidance literature:: Multi-step reaction with 7 steps

1: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C

2: 93 percent / H₂ / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr

3: DCC, HOBt / H₂O; various solvent(s) / 5 h / Ambient temperature

4: MsOH / ethanol / 7.5 h / 35 - 40 °C

5: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature

6: MsOH / ethanol / 35 - 40 °C

7: ethanol; ethyl acetate / 55 °C

With methanesulfonic acid; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(97)00359-1