2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide

Base Information

• Chemical Name: 2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide
• CAS No.: 298197-04-3
• Molecular Formula: C18H19BrN2S
• Molecular Weight: 375.33
• European Community (EC) Number: 663-387-0
• DSSTox Substance ID: DTXSID801044314
• ChEMBL ID: CHEMBL1455549
• Mol file: 298197-04-3.mol

Synonyms:298197-04-3;Fatostatin HBr;Fatostatin Hydrobromide;Fatostatin (hydrobromide);Fatostatin A Hydrobromide;2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide;Fatostatin A HBr;125B11 (hydrobromide);298197-04-3 (HBr);2-Propyl-4-(4-p-tolyl-thiazol-2-yl)-pyridine;SMR000221636;MLS000332366;4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-pyridine, hydrobromide;FatostatinHydrobromide;4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;hydrobromide;125B11 hydrobromide;MLS003593148;CHEMBL1455549;DTXSID801044314;BCP20908;EX-A3587;YLA19704;HY-14452A;s8284;AKOS024260295;Fatostatin A;CCG-268352;AC-36895;AS-58430;CS-0028964;FT-0668473;MLS-0221672.0001;A934893;2-(2-Propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide;4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide;4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide (1:1);4-[4-(4-METHYLPHENYL)-1,3-THIAZOL-2-YL]-2-PROPYLPYRIDINE HYDROBROMIDE;Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-, hydrobromide (1:1)

Chemical Property of 2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide

Chemical Property:

• PSA: 54.02000
• LogP: 6.09110
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ≥10mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 374.04523
• Heavy Atom Count: 22
• Complexity: 314

Purity/Quality:

99% ^*data from raw suppliers

Fatostatin A ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C.Br
• Uses: Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP). Fatostatin A reverses hyperglycemia in diabetic mice. Cell permeable. Fatostatin A is used for the treatment and/or prevention of one or more metabolic disorders. Fatostatin hydrobromide has been used:to study its anti-cancer activity and effects on mitotic microtubule spindleto study its effects on stomatal developmentto prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)

Technology Process of 2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide

There total 1 articles about 2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

prothionamide (14222-60-7) + 4-(bromoacetyl)toluene (619-41-0) → 4-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-2-propylpyridine hydrobromide (298197-04-3)

Guidance literature:

In ethanol; at 70 ℃; for 0.5h; Product distribution / selectivity;

upstream raw materials:

prothionamide

4-(bromoacetyl)toluene

Refernces