Methyl 2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranoside [1,1'-biphenyl]-4-carboxylate

Base Information

• Chemical Name: Methyl 2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranoside [1,1'-biphenyl]-4-carboxylate
• CAS No.: 129468-51-5
• Molecular Formula: C19H19FO4
• Molecular Weight: 330.356
• Mol file: 129468-51-5.mol

Synonyms:Methyl 2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranoside [1,1'-biphenyl]-4-carboxylate

Chemical Property of Methyl 2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranoside [1,1'-biphenyl]-4-carboxylate

Chemical Property:

• Melting Point: 58-60℃

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranoside [1,1'-biphenyl]-4-carboxylate

There total 8 articles about Methyl 2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranoside [1,1'-biphenyl]-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside (129468-49-1) → methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside (129468-51-5,168786-98-9) + Biphenyl-4-carboxylic acid (2S,5R)-5-methoxy-2,5-dihydro-furan-2-ylmethyl ester

Guidance literature:

With 2,2-difluoro-1,3-dimethyl-imidazolidine; In acetonitrile; at 85 ℃; for 4h;

DOI:10.1081/NCN-120022607

Reference yield: 57.0%

methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside (125611-95-2) → methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside (129468-51-5,168786-98-9)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; for 120h; Ambient temperature;

Reference yield: 43.0%

Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside (129468-49-1) → Methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside (129468-51-5,168786-98-9)

Guidance literature:

With diethylamino-sulfur trifluoride; In toluene; for 1h; Ambient temperature;

upstream raw materials:

Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside

Methyl 2-Deoxy-3-O-(methylsulfonyl)-5-O-(4-phenylbenzoyl)-α-D-erythro-pentofuranoside

methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside

Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-glyceropentofuranosid-3-ulose