Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester
CAS No.:466639-00-9
Molecular Formula:C₂₀H₁₉FO₅
Molecular Weight:358.366
Hs Code.:

Synonyms:Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester

There total 1 articles about Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-24-7
acetic anhydride

: 129468-51-5,168786-98-9
Methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside

: 466639-00-9
Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With sulfuric acid; In acetic acid; at 0 ℃; for 2.5h;
DOI:10.1016/S0040-4039(03)00428-3

Reference yield:

: 466639-00-9
Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester

: 92562-88-4
9-(2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranosyl)guanine

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. HCl / toluene; dioxane; cyclohexane / 8 h / 0 °C

2.1: o-H₃PO₄; nBu₃N; 4 Angstroem molecular sieve / acetonitrile; various solvent(s) / 6 h / 0 °C

2.2: acetonitrile; various solvent(s)

3.1: KOH / H₂O / 48 h / 50 °C

4.1: PNPase; CaCl₂ / H₂O / 5 h / 40 - 60 °C / Enzymatic reaction

With hydrogenchloride; potassium hydroxide; tributyl-amine; phosphoric acid; 4 A molecular sieve; PNPase; calcium chloride; In 1,4-dioxane; cyclohexane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(03)00428-3

Reference yield:

: 466639-00-9
Biphenyl-4-carboxylic acid (2R,3S)-5-acetoxy-3-fluoro-tetrahydro-furan-2-ylmethyl ester

: Phosphoric acid mono-((4S,5R)-4-fluoro-5-hydroxymethyl-tetrahydro-furan-2-yl) ester; compound with cyclohexylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. HCl / toluene; dioxane; cyclohexane / 8 h / 0 °C

2.1: o-H₃PO₄; nBu₃N; 4 Angstroem molecular sieve / acetonitrile; various solvent(s) / 6 h / 0 °C

2.2: acetonitrile; various solvent(s)

3.1: methanol / 1200 h / 20 °C

With hydrogenchloride; tributyl-amine; phosphoric acid; 4 A molecular sieve; In 1,4-dioxane; methanol; cyclohexane; toluene; acetonitrile;
DOI:10.1016/S0040-4039(03)00428-3