(βS)-β-[(1,1-tert-DiMethylethoxycarbonyl)aMino]-4-hydroxy-benzenepropanoic Acid Methyl Ester

Base Information

Chemical Name:(βS)-β-[(1,1-tert-DiMethylethoxycarbonyl)aMino]-4-hydroxy-benzenepropanoic Acid Methyl Ester
CAS No.:474295-85-7
Molecular Formula:C15H21NO5
Molecular Weight:295.335
Hs Code.:
Mol file:474295-85-7.mol

Synonyms:(βS)-β-[(1,1-tert-Butyloxycarbonyl)aMino]-4-hydroxy-benzenepropanoic Acid Methyl Ester;(βS)-β-[(1,1-tert-DiMethylethoxycarbonyl)aMino]-4-hydroxy-benzenepropanoic Acid Methyl Ester

Suppliers and Price of (βS)-β-[(1,1-tert-DiMethylethoxycarbonyl)aMino]-4-hydroxy-benzenepropanoic Acid Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(βS)-β-[(1,1-tert-Butyloxycarbonyl)amino]-4-hydroxy-benzenepropanoicAcidMethylEster
25mg
$ 180.00

TRC
(βS)-β-[(1,1-tert-Butyloxycarbonyl)amino]-4-hydroxy-benzenepropanoicAcidMethylEster
250mg
$ 1390.00

Medical Isotopes, Inc.
(βS)-β-[(1,1-tert-Butyloxycarbonyl)amino]-4-hydroxy-benzenepropanoicAcidMethylEster
25 mg
$ 675.00

Total 1 raw suppliers

Chemical Property of (βS)-β-[(1,1-tert-DiMethylethoxycarbonyl)aMino]-4-hydroxy-benzenepropanoic Acid Methyl Ester

Chemical Property:

Boiling Point:447.4±40.0 °C(Predicted)
PKA:9.85±0.26(Predicted)
PSA：88.35000
Density:1.168±0.06 g/cm3(Predicted)
LogP:2.72550
Storage Temp.:Refrigerator
Solubility.:Chloroform, DMSO, Methanol

Purity/Quality:: (βS)-β-[(1,1-tert-Butyloxycarbonyl)amino]-4-hydroxy-benzenepropanoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (βS)-β-[(1,1-tert-DiMethylethoxycarbonyl)amino]-4-hydroxy-benzenepropanoic Acid Methyl Ester is used in the preparation of Alzheimer's disease acetylcholinesterase/serotonin transporter inhibitors.

Technology Process of (βS)-β-[(1,1-tert-DiMethylethoxycarbonyl)aMino]-4-hydroxy-benzenepropanoic Acid Methyl Ester

There total 3 articles about (βS)-β-[(1,1-tert-DiMethylethoxycarbonyl)aMino]-4-hydroxy-benzenepropanoic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 177966-65-3
methyl (3S)-3-amino-3-(4-hydroxyphenyl)propanoate

: 474295-85-7
methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1021/ol026418e

Reference yield:

: 499995-80-1
(S)-3-Boc-amino-3-(4-hydroxyphenyl)-propanoic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 474295-85-7
methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate

Guidance literature:: In methanol; hexane; benzene; at 25 ℃; for 1h;

Reference yield:

: 152786-27-1
(S)-3-amino-3-(4-hydroxyphenyl)propanoic acid

: 474295-85-7
methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetyl chloride / methanol / 12 h / 65 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; acetyl chloride; In methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.0c01581