2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one

Base Information

• Chemical Name: 2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one
• CAS No.: 1313399-38-0
• Molecular Formula: C15H20BNO3
• Molecular Weight: 273.1352
• Mol file: 1313399-38-0.mol

Synonyms:2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one

Chemical Property of 2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one

Chemical Property:

• PSA: 38.77000
• LogP: 1.50930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoindolin-1-One ^*data from reagent suppliers

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Technology Process of 2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one

There total 11 articles about 2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-[(methylamino)methyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate → 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one (1313399-38-0)

Guidance literature:

In acetonitrile; for 2h; Reflux;

Reference yield: 82.77%

N-methyl-6-bromoisoindoline-1-one (1254319-51-1) + bis(pinacol)diborane (73183-34-3) → 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one (1313399-38-0)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 1.5h;

Reference yield:

→ 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoindolin-1-one (1002309-19-4) + 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one (1313399-38-0)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 1-(2-([2,2'-bipyridin]-5-yl)phenyl)-3-cyclohexylthiourea; In para-xylene; at 25 ℃; for 24h; Overall yield = 39 %;

upstream raw materials:

N-methyl-6-bromoisoindoline-1-one

bis(pinacol)diborane

6-bromo-1-oxo-2,3-dihydro-1H-isoindole

methyl-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

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