Prednisone 17, 21-Diacetate

Base Information

• Chemical Name: Prednisone 17, 21-Diacetate
• CAS No.: 6677-19-6
• Molecular Formula: C25H30O7
• Molecular Weight: 442.509
• Mol file: 6677-19-6.mol

Synonyms:Prednisone 17, 21-Diacetate;17,21-Bis(acetyloxy)-pregna-1,4-diene-3,11,20-trione;17,21-Dihydroxy-pregna-1,4-diene-3,11,20-trione Diacetate

Chemical Property of Prednisone 17, 21-Diacetate

Chemical Property:

• PSA: 103.81000
• LogP: 2.90740
• Storage Temp.: Refrigerator
• Solubility.: Chloroform

Purity/Quality:

99% ^*data from raw suppliers

Prednisone17,21-Diacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Adrenocortical steroid. Antiinflammatory.

Technology Process of Prednisone 17, 21-Diacetate

There total 4 articles about Prednisone 17, 21-Diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

prednisone acetate (125-10-0) + acetic acid (64-19-7,77671-22-8) → 17α,21-diacetoxypregna-1,4-diene-3,11,20-trione (6677-19-6)

Guidance literature:

With trifluoroacetic anhydride; toluene-4-sulfonic acid; at 0 - 20 ℃; for 3.5h;

Reference yield: 98.4%

Prednison (53-03-2) + acetic anhydride (108-24-7) → 17α,21-diacetoxypregna-1,4-diene-3,11,20-trione (6677-19-6)

Guidance literature:

With pyridine; at 85 - 90 ℃; for 2.5h; Reagent/catalyst; Temperature;

Reference yield:

→ 1,2-Dehydrocortison-17,21-diacetat (6677-19-6)

Guidance literature:

aus 2,4-Dibrom-4,5α-cortison-17,21-diacetat;

upstream raw materials:

prednisone acetate

acetic acid

Prednison

acetic anhydride

Downstream raw materials:

Acetic acid 2-((4aR,4bS,5S,6aS,6bR,9aS,10aS,10bS)-8-benzyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,8,9,9a,10,10a,10b,11,12-tetradecahydro-7-oxa-8-aza-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester

21-acetoxy-11β-hydroxyl-1,4,16-pregnatriene-3,20-dione

21-acetoxypregna-1,4,16-triene-3,11,20-trione

Refernces

• 1、 -. "ISOXAZOLIDINE DERIVATIVES". Page/Page column 37. . Retrieved 2012/09/25.
• 2、 -. "ISOXAZOLIDINE DERIVATIVES". Page/Page column 43. . Retrieved 2011/04/18.