Technology Process of AZD3264
There total 11 articles about AZD3264 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran; water; isopropyl alcohol;
at 65 ℃;
Inert atmosphere;
Large scale;
DOI:10.1021/op500105n
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium tert-butylate / 2-methyltetrahydrofuran / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); triethylamine / 2-methyltetrahydrofuran / 50 °C / Inert atmosphere
3: n-hexyllithium / tetrahydrofuran / Inert atmosphere; Large scale
4: potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 2-methyltetrahydrofuran; water / 35 °C / Inert atmosphere; Large scale
5: hydrogenchloride / tetrahydrofuran; water; isopropyl alcohol / 65 °C / Inert atmosphere; Large scale
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium tert-butylate; n-hexyllithium; potassium carbonate; triethylamine;
In
tetrahydrofuran; 2-methyltetrahydrofuran; water; isopropyl alcohol;
2: |Suzuki Coupling / 4: |Suzuki Coupling;
DOI:10.1021/op500105n
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium tert-butylate / 2-methyltetrahydrofuran / 70 - 75 °C / Inert atmosphere; Large scale
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 2-methyltetrahydrofuran; water / 20 h / 50 - 70 °C / Inert atmosphere; Large scale
3: n-hexyllithium / tetrahydrofuran / Inert atmosphere; Large scale
4: potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 2-methyltetrahydrofuran; water / 35 °C / Inert atmosphere; Large scale
5: hydrogenchloride / tetrahydrofuran; water; isopropyl alcohol / 65 °C / Inert atmosphere; Large scale
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium tert-butylate; n-hexyllithium; sodium carbonate; potassium carbonate;
In
tetrahydrofuran; 2-methyltetrahydrofuran; water; isopropyl alcohol;
2: |Suzuki Coupling / 4: |Suzuki Coupling;
DOI:10.1021/op500105n
