136434-77-0

Basic information

• Product Name: 1-BROMO-2-FLUORO-4-IODOBENZENE
• Synonyms: 1-BROMO-2-FLUORO-4-IODOBENZENE;4-Bromo-3-fluoroiodobenzene;1-Bromo-2-fluoro-4-iodobenzene,98%;1-Bromo-2-fluoro-4-iodobenzene 98%;2-Fluoro-4-iodobromobenzene;1-BROMO-2-FLUORO-4-I;4-Bromo-3-fluoroiodobenzene 98%;3-fluoro-4-BroMo--1-iodobenzene
• CAS NO: 136434-77-0
• Molecular Formula: C₆H₃BrFI
• Molecular Weight: 300.89
• EINECS: -0
• Product Categories: Aromatic Halides (substituted);API intermediates;Miscellaneous;Bromine Compounds;Fluorine Compounds;Iodine Compounds;Aryl;C6;Halogenated Hydrocarbons;Fluorine series
• Mol File: 136434-77-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 34-38 °C(lit.)
• Boiling Point: 80°C 2,5mm
• Flash Point: >230 °F
• Appearance: Pale brown/Crystalline Low Melting Solid
• Density: 2.2691 (estimate)
• Vapor Pressure: 0.0651mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: Room temperature.
• Sensitive: Light Sensitive
• BRN: 4740251
• CAS DataBase Reference: 1-BROMO-2-FLUORO-4-IODOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-FLUORO-4-IODOBENZENE(136434-77-0)
• EPA Substance Registry System: 1-BROMO-2-FLUORO-4-IODOBENZENE(136434-77-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-52/53-36/37/38
• Safety Statements: 36-37/39-26-24/25
• WGK Germany: 2
• HazardClass: IRRITANT, LIGHT SENSITIVE
• Hazardous Substances Data: 136434-77-0(Hazardous Substances Data)

Usage

Chemical Properties

Pale brown crystalline low melting solid

InChI:InChI=1/C6H3BrFI/c7-5-2-1-4(9)3-6(5)8/h1-3H

Upstream product

• 656-65-5 3-fluoro-4-bromophenylamine 
• 29632-74-4 2-fluro-4-iodoaniline 
• 348-54-9 2-Fluoroaniline 
• 372-19-0 meta-fluoroaniline 
• 351-28-0 N-(3-fluorophenyl)acetamide 
• 351-30-4 N-(4-bromo-3-fluorophenyl)ethanamide 

Downstream Products

• 136434-78-1 1-bromo-2-fluoro-4-pent-1-ynylbenzene 
• 217816-54-1 3-bromo-2-fluoro-6-iodo-benzoic acid 
• 1369530-77-7 3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one 
• 1056159-19-3 4-(4-bromo-3-fluorophenyl)pyridine 
• 265322-55-2 butyl 3-(4-bromo-3-fluorophenyl)-2-methylacrylate 
• 1007346-59-9 N-(4-bromo-3-fluorophenyl)-N',N'-dimethyl-N-(pyridin-3-yl)ethane-1,2-diamine 
• 1007346-58-8 N-(4-bromo-3-fluorophenyl)-N',N'-dimethyl-N-phenylethane-1,2-diamine 
• 917562-25-5 (4-bromo-3-fluorophenyl)(methyl)sulfane 
• 934162-47-7 tert-butyl 5-(4-bromo-3-fluorophenyl)-5-oxopentylcarbamate 
• 1264652-74-5 C₁₁H₆Br₂FN 
• 1557036-53-9 4-bromo-7-(4-bromo-3-fluorophenyl)-5,6-difluorobenzo[c]-[1,2,5]thiadiazole 
• 1401100-53-5 4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholin-3-one 
• 1401100-50-2 1-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)-4-methylpiperazin-2-one 
• 1401100-60-4 4-(2-fluoro-4-vinylphenyl)morpholin-3-one 

Relevant articles and documents

METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to metallo-β-lactamase inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

Largely blue-shifted emission through minor structural modifications: Molecular design, synthesis, aggregation-induced emission and deep-blue OLED application

By simply introducing additional groups with different size and conjugation degree to the 2,2′-positions of BTPE, four BTPE derivatives are prepared which give blue or deep-blue EL emissions when used as emitters in non-doped OLEDs, as the result of the tuned dihedral angles of the biphenyl cores (up to ～89°), providing a new approach to design AIE luminogens with blue and deep-blue emissions. The Royal Society of Chemistry.

Anisotropic organic compounds

STR1 The invention describes liquid crystalline compounds or formula (I), where A, D and G are independently selected from phenyl, thiophene, hydrogenated phenyl, chlorinated phenyl and fluorinated phenyl, B and E are independently selected from a single bond C= C. C C.C00, azoxy and diazo, k and m are independently selected from 1 and 0, such that m+n is 1 or 2, and R1 and R2 are independently selected from R, R0, alkynyl, thioalkyl, hydrogen, CN, NCS and SCN; provided that at least one of R1 and R2 is selected from CN, NCS and SCN and that at least one of A, D and G is phenyl; and excluding where at least one of R1 and R2 is independently selected as CN and one of A, D or G is not thiophene, and where m is 0, A, and D are phenyl, B is a single bond and only one of R1 or R2 is NCS. Also described are compounds suitable for inclusion in a device utilizing pretransitional characteristics of liquid crystalline materials in the isotropic phase, of general formula (II) where J and Y are independently selected from phenyl, thiophene, hydrogenated phenyl, chlorinated phenyl and fluorinated phenyl, X is selected from C= C. C C.COO azoxy and diazo, k is 1 or 0 and R3 and R4 are independently selected from R, RO, alkynyl, thioalkyl, hydrogen, CN, NCS and SCN; provided that at least one of R3 and R4 is selected from CN, NCS and SCN and that at least one of J and Y is phenyl.