4'-BroMo-4-Methanesulfonyl-biphenyl

Base Information

• Chemical Name: 4'-BroMo-4-Methanesulfonyl-biphenyl
• CAS No.: 1774-28-3
• Molecular Formula: C13H11BrO2S
• Molecular Weight: 311.199
• Hs Code.: 2904909090
• Mol file: 1774-28-3.mol

Synonyms:4'-BroMo-4-Methanesulfonyl-biphenyl;4-BroMo-4'-(Methylsulfonyl)-1,1'-biphenyl

Chemical Property of 4'-BroMo-4-Methanesulfonyl-biphenyl

Chemical Property:

• PSA: 42.52000
• LogP: 4.60040

Purity/Quality:

98.5% ^*data from raw suppliers

4'-Bromo-4-methanesulfonylbiphenyl 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-BroMo-4-Methanesulfonyl-biphenyl

There total 4 articles about 4'-BroMo-4-Methanesulfonyl-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.85%

(4,4,5,5-tetramethyl-2-[4-(methylsulfonyl)phenyl])-1,3,2-dioxaborolane (603143-27-7) + 1,4-bromoiodobenzene (589-87-7) → 4’-bromobiphenyl-4-ylmethylsulfone (1774-28-3)

Guidance literature:

With palladium diacetate; at 100 ℃; Sealed tube; Inert atmosphere;

Reference yield: 46.0%

1,4-bromoiodobenzene (589-87-7) + 4-methanesulphonylphenylboronic acid (149104-88-1) → 4’-bromobiphenyl-4-ylmethylsulfone (1774-28-3)

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene; at 80 ℃; for 1h; Heating / reflux;

Reference yield:

4-bromoohenyl methyl sulfone (3466-32-8) → 4’-bromobiphenyl-4-ylmethylsulfone (1774-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium acetate / 1,4-dioxane / 0.33 h / Inert atmosphere

1.2: 90 °C

2.1: palladium diacetate / 100 °C / Sealed tube; Inert atmosphere

With potassium acetate; palladium diacetate; In 1,4-dioxane;

upstream raw materials:

1,4-bromoiodobenzene

4-methanesulphonylphenylboronic acid

(4,4,5,5-tetramethyl-2-[4-(methylsulfonyl)phenyl])-1,3,2-dioxaborolane

4-bromoohenyl methyl sulfone

Refernces

• 1、 -. "OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY". Page/Page column 114. . Retrieved 2015/01/07.