N-(1-Benzylpiperidin-4-yl)-3-nitropyridin-2-amine

Base Information

• Chemical Name: N-(1-Benzylpiperidin-4-yl)-3-nitropyridin-2-amine
• CAS No.: 185058-54-2
• Molecular Formula: C17H20N4O2
• Molecular Weight: 312.3663
• Hs Code.: 2933990090
• Mol file: 185058-54-2.mol

Synonyms:N-(1-Benzylpiperidin-4-yl)-3-nitropyridin-2-amine;(1-Benzyl-piperidin-4-yl)-(3-nitro-pyridin-2-yl)-aMine

Chemical Property of N-(1-Benzylpiperidin-4-yl)-3-nitropyridin-2-amine

Chemical Property:

• PSA: 73.98000
• LogP: 3.60040

Purity/Quality:

99%, ^*data from raw suppliers

1-Benzyl-N-(3-nitropyridin-2-yl)piperidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(1-Benzylpiperidin-4-yl)-3-nitropyridin-2-amine

There total 1 articles about N-(1-Benzylpiperidin-4-yl)-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + 4-amino-1-benzylpiperidine (50541-93-0) → (1-Benzyl-piperidin-4-yl)-(3-nitro-pyridin-2-yl)-amine (185058-54-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.02.030

Reference yield:

(1-Benzyl-piperidin-4-yl)-(3-nitro-pyridin-2-yl)-amine (185058-54-2) → α-(R)-(3-(S)-((4-Imidazo[4,5-b]pyridin-3-yl-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic Acid

Guidance literature:

Multi-step reaction with 5 steps

1: SnCl₂; aq. HCl

2: aq. HCl / Heating

3: HCO₂NH₄ / Pd/C / methanol

4: NaBH(OAc)3 / CH₂Cl₂

5: TFA / methoxybenzene

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; trifluoroacetic acid; tin(ll) chloride; palladium on activated charcoal; In methanol; dichloromethane; methoxybenzene;

DOI:10.1016/j.bmcl.2005.02.030

Reference yield:

(1-Benzyl-piperidin-4-yl)-(3-nitro-pyridin-2-yl)-amine (185058-54-2) → (R)-Cyclohexyl-[(3S,4S)-3-(4-imidazo[4,5-b]pyridin-3-yl-piperidin-1-ylmethyl)-4-phenyl-pyrrolidin-1-yl]-acetic acid 4-methoxy-benzyl ester (301220-39-3)

Guidance literature:

Multi-step reaction with 4 steps

1: SnCl₂; aq. HCl

2: aq. HCl / Heating

3: HCO₂NH₄ / Pd/C / methanol

4: NaBH(OAc)3 / CH₂Cl₂

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; tin(ll) chloride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.02.030

upstream raw materials:

2-Chloro-3-nitropyridine

4-amino-1-benzylpiperidine

Downstream raw materials:

3-(1-benzyl-piperidin-4-yl)-3H-imidazo[4,5-b]pyridine

(R)-Cyclohexyl-[(3S,4S)-3-(4-imidazo[4,5-b]pyridin-3-yl-piperidin-1-ylmethyl)-4-phenyl-pyrrolidin-1-yl]-acetic acid 4-methoxy-benzyl ester

3-(piperidin-4-yl)-3H-imidazo[4,5-b]pyridine

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