6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

Base Information

Chemical Name:6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
CAS No.:1254036-71-9
Molecular Formula:C26H28N6O
Molecular Weight:440.548
Hs Code.:
Mol file:1254036-71-9.mol

Synonyms:6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole;GSK2269557 (free base)

Suppliers and Price of 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1H-Indazole
10mg
$ 740.00

Matrix Scientific
1H-Indazole
5mg
$ 482.00

DC Chemicals
PI3KδinhibitorGS2269557 >98%
1 g
$ 3500.00

DC Chemicals
PI3KδinhibitorGS2269557 >98%
100 mg
$ 950.00

Crysdot
GSK2269557freebase 98+%
100mg
$ 972.00

Crysdot
GSK2269557freebase 98+%
5mg
$ 132.00

Crysdot
GSK2269557freebase 98+%
10mg
$ 201.00

Crysdot
GSK2269557freebase 98+%
25mg
$ 340.00

Crysdot
GSK2269557freebase 98+%
50mg
$ 589.00

ChemScene
Nemiralisib 99.50%
25mg
$ 492.00

Total 5 raw suppliers

Chemical Property of 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

Chemical Property:

Boiling Point:706.2±70.0 °C(Predicted)
PKA:12.90±0.40(Predicted)
PSA：76.98000
Density:1.281±0.06 g/cm3(Predicted)
LogP:4.76800

Purity/Quality:

97% ^*data from raw suppliers

1H-Indazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

There total 1 articles about 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35572-79-3
5-chloro-2-methyl-1,3-dinitro-benzene

: 1254036-71-9
6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole

Guidance literature:: Multi-step reaction with 11 steps

1.1: diammonium sulfide / water; ethanol

2.1: sodium nitrite

3.1: nickel; hydrazine hydrate

4.1: acetic acid; acetic anhydride

5.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / tetrahydrofuran

6.1: lithium hexamethyldisilazane; zinc(II) chloride / tetrahydrofuran / -10 °C

6.2: 60 °C

7.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 °C

8.1: bromine; triphenylphosphine / dichloromethane

9.1: triethylamine / dimethyl sulfoxide

10.1: palladium diacetate; tricyclohexylphosphine; potassium hydrogenfluoride; potassium phosphate / isopropyl alcohol; water / 80 °C

11.1: cetyltrimethylammonim bromide; potassium hydroxide; pentan-3-one / 2-methyltetrahydrofuran / 80 °C

With diammonium sulfide; potassium phosphate; potassium hydrogenfluoride; bromine; cetyltrimethylammonim bromide; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; acetic anhydride; nickel; diisobutylaluminium hydride; hydrazine hydrate; acetic acid; triethylamine; triphenylphosphine; pentan-3-one; potassium hydroxide; sodium hydroxide; zinc(II) chloride; lithium hexamethyldisilazane; sodium nitrite; tricyclohexylphosphine; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene; 10.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.oprd.0c00486