GSK-2269557

Base Information

• Chemical Name: GSK-2269557
• CAS No.: 1254036-77-5
• Molecular Formula: C26H28N6O.HCl
• Molecular Weight: 477.00106
• Mol file: 1254036-77-5.mol

Synonyms:GSK-2269557;2-(6-(1H-Indol-4-yl)-1H-indazol-4-yl)-5-((4-isopropylpiperazin-1-yl)methyl)oxazole hydrochloride;GSK2269557 HCL;6-(1H-Indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-1H-indazole hydrochloride (1:1);GSK-2269557 HCl salt

Chemical Property of GSK-2269557

Chemical Property:

• PSA: 76.98000
• LogP: 5.57000
• Solubility.: ≤0.2mg/ml in ethanol;20mg/ml in DMSO;14mg/ml in dimethyl formamide

Purity/Quality:

99%, ^*data from raw suppliers

GSK-2269557 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GSK-2269557

There total 4 articles about GSK-2269557 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole (1254036-71-9) → 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hydrochloride (1254036-77-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 0.2 - 60 ℃; for 1h; Inert atmosphere;

Reference yield:

indole-4-boronic acid pinacol ester (388116-27-6) → 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hydrochloride (1254036-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 1.5 h / 100 - 140 °C / Microwave irradiation

2: hydrogenchloride / tetrahydrofuran; diethyl ether / 1 h / 0.2 - 60 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;

Reference yield:

6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole (1254036-86-6) → 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hydrochloride (1254036-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 1.5 h / 100 - 140 °C / Microwave irradiation

2: hydrogenchloride / tetrahydrofuran; diethyl ether / 1 h / 0.2 - 60 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;

upstream raw materials:

6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole

indole-4-boronic acid pinacol ester

6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

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