2-Methoxy-6-trifluoroMethyl-3H-pyriMidin-4-one

Base Information

• Chemical Name: 2-Methoxy-6-trifluoroMethyl-3H-pyriMidin-4-one
• CAS No.: 175354-56-0
• Molecular Formula: C6H5F3N2O2
• Molecular Weight: 194.113
• Hs Code.: 2933599590
• Mol file: 175354-56-0.mol

Synonyms:2-Methoxy-6-trifluoroMethyl-3H-pyriMidin-4-one;2-Methoxy-6-(trifluoroMethyl)pyriMidin-4(3H)-one

Chemical Property of 2-Methoxy-6-trifluoroMethyl-3H-pyriMidin-4-one

Chemical Property:

• PSA: 55.24000
• LogP: 1.20960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-methoxy-6-trifluoromethyl-pyrimidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-6-trifluoroMethyl-3H-pyriMidin-4-one

There total 2 articles about 2-Methoxy-6-trifluoroMethyl-3H-pyriMidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + 2-methyl-isourea (2440-60-0) → 2-Methoxy-6-trifluoromethyl-3H-pyrimidin-4-one (175354-56-0)

Guidance literature:

With calcium oxide; In ethanol; water; for 72h; Ambient temperature;

DOI:10.1021/jm950675q

Reference yield:

O-methylisourea hemisulfate (52328-05-9,24285-39-0) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 2-methoxy-6-trifluoromethylpyrimidin-4-ol (175354-56-0)

Guidance literature:

O-methylisourea hemisulfate; ethyl 4,4,4-trifluoroacetoacetate; With sodium methylate; In methanol; at 80 ℃; for 20h;

With hydrogenchloride; In methanol; water;

Reference yield: 83.0%

2-Methoxy-6-trifluoromethyl-3H-pyrimidin-4-one (175354-56-0) → 6-trifluoromethyluracil (672-45-7)

Guidance literature:

With sulfuric acid; at 70 ℃; for 2h;

DOI:10.1021/jm950675q

upstream raw materials:

ethyl 4,4,4-trifluoroacetoacetate

2-methyl-isourea

O-methylisourea hemisulfate

Downstream raw materials:

6-trifluoromethyluracil

C₆H₄ClF₃N₂O