4-Methylcyclohexanone thiosemicarbazone

Base Information

• Chemical Name: 4-Methylcyclohexanone thiosemicarbazone
• CAS No.: 22397-22-4
• Molecular Formula: C8H15N3S
• Molecular Weight: 185.293
• Mol file: 22397-22-4.mol

Synonyms:4-Methylcyclohexanone thiosemicarbazone

Chemical Property of 4-Methylcyclohexanone thiosemicarbazone

Chemical Property:

• Melting Point: 161 °C
• PSA: 82.50000
• LogP: 2.47690

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methylcyclohexanone thiosemicarbazone

There total 1 articles about 4-Methylcyclohexanone thiosemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiosemicarbazide (79-19-6) + 1-methylcyclohexan-4-one (589-92-4) → (+/-)-1-methyl-cyclohexanone-(4)-thiosemicarbazone (22397-22-4)

Guidance literature:

With ethanol;

DOI:10.1039/jr9430000565

Reference yield: 95.0%

(+/-)-1-methyl-cyclohexanone-(4)-thiosemicarbazone (22397-22-4) + α-bromoacetophenone (70-11-1) → N-(4-methyl-cyclohexylidene)-N'-(4-phenyl-thiazol-2-yl)-hydrazine

Guidance literature:

In isopropyl alcohol; Heating;

DOI:10.1016/S0014-827X(02)01288-0

Reference yield: 86.0%

3-bromoacetylcoumarin (29310-88-1) + (+/-)-1-methyl-cyclohexanone-(4)-thiosemicarbazone (22397-22-4) → 3-(2-(2-(4-methylcyclohexylidene)hydrazynyl)thiazol-4-yl)-2H-chromen-2-one (886134-15-2)

Guidance literature:

In isopropyl alcohol; at 20 ℃; for 2h;

DOI:10.1002/jhet.110

upstream raw materials:

thiosemicarbazide

1-methylcyclohexan-4-one

Downstream raw materials:

2-[N'-(4-Methyl-cyclohexylidene)-hydrazino]-5-phenyl-thiazole-4-carboxylic acid methyl ester; hydrochloride

C₁₆H₁₈ClN₃S

3-(2-(2-(4-methylcyclohexylidene)hydrazynyl)thiazol-4-yl)-2H-chromen-2-one

C₁₃H₁₉N₃O₂S

Refernces

• 1、 Carradori, Simone,Bizzarri, Bruna,D'Ascenzio, Melissa,De Monte, Celeste,Grande, Rossella,Rivanera, Daniela,Zicari, Alessanda,Mari, Emanuela,Sabatino, Manuela,Patsilinakos, Alexandros,Ragno, Rino,Secci, Daniela. "Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity". . p. 274 - 292. Retrieved 2017/10/05.
• 2、 De Monte, Celeste,Carradori, Simone,Secci, Daniela,D'Ascenzio, Melissa,Guglielmi, Paolo,Mollica, Adriano,Morrone, Stefania,Scarpa, Susanna,Aglianò, Anna Maria,Giantulli, Sabrina,Silvestri, Ida. "Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma". . p. 245 - 262. Retrieved 2015/11/03.