6-(4-TRIFLUOROMETHYL-PHENYL)-PYRIDINE-3-CARBALDEHYDE

Base Information

• Chemical Name: 6-(4-TRIFLUOROMETHYL-PHENYL)-PYRIDINE-3-CARBALDEHYDE
• CAS No.: 356058-14-5
• Molecular Formula: C13H8F3NO
• Molecular Weight: 251.208
• Hs Code.: 2933399090
• Mol file: 356058-14-5.mol

Synonyms:6-(4-TRIFLUOROMETHYL-PHENYL)-PYRIDINE-3-CARBALDEHYDE;6-[4-(TRIFLUOROMETHYL)PHENYL]NICOTINALDEHYDE;6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIDINE-3-CARBOXALDEHYDE;6-[4-(TrifluoroMethyl)phenyl]-3-pyridinecarbaldehyde

Chemical Property of 6-(4-TRIFLUOROMETHYL-PHENYL)-PYRIDINE-3-CARBALDEHYDE

Chemical Property:

• PSA: 29.96000
• LogP: 3.57990

Purity/Quality:

97% ^*data from raw suppliers

6-[(4-Trifluoromethyl)phenyl]nicotinaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(4-TRIFLUOROMETHYL-PHENYL)-PYRIDINE-3-CARBALDEHYDE

There total 5 articles about 6-(4-TRIFLUOROMETHYL-PHENYL)-PYRIDINE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-trifluoromethylphenylboronic acid (128796-39-4) + 6-bromonicotinaldehyde (149806-06-4) → 6-(4-(trifluoromethyl)phenyl)nicotinaldehyde (356058-14-5)

Guidance literature:

6-bromonicotinaldehyde; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

4-trifluoromethylphenylboronic acid; In tetrahydrofuran; water; at 80 ℃; Inert atmosphere;

DOI:10.1021/jm201184h

Reference yield: 63.0%

→ 6-(4-(trifluoromethyl)phenyl)nicotinaldehyde (356058-14-5)

Guidance literature:

Reference yield: 52.0%

6-bromonicotinaldehyde (149806-06-4) + 4-trifluoromethylphenylboronic acid pinacol ester (214360-65-3) → 6-(4-(trifluoromethyl)phenyl)nicotinaldehyde (356058-14-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 110 ℃; for 4h; Inert atmosphere;

upstream raw materials:

4-trifluoromethylphenylboronic acid

6-bromonicotinaldehyde

5-hydroxymethyl-2-(4-trifluoromethylphenyl)pyridine

methyl 6-(4-(trifluoromethyl)phenyl)nicotinate

Downstream raw materials:

5-hydroxymethyl-2-(4-trifluoromethylphenyl)pyridine

1-(6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)propan-1-ol

(R,S)-(4-tert-butyl-phenyl)-[6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol

C₂₂H₁₅F₃N₂O

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