(6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIDIN-3-YL)METHANOL

Base Information

• Chemical Name: (6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIDIN-3-YL)METHANOL
• CAS No.: 356058-13-4
• Molecular Formula: C13H10F3NO
• Molecular Weight: 253.224
• Hs Code.: 2933399990
• Mol file: 356058-13-4.mol

Synonyms:(6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIDIN-3-YL)METHANOL;5-HYDROXYMETHYL-2-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE;[6-[4-(TrifluoroMethyl)phenyl]-3-pyridyl]Methanol

Chemical Property of (6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIDIN-3-YL)METHANOL

Chemical Property:

• Boiling Point: 347.1±42.0 °C(Predicted)
• PKA: 13.51±0.10(Predicted)
• PSA: 33.12000
• Density: 1.296±0.06 g/cm3(Predicted)
• LogP: 3.25970

Purity/Quality:

97% ^*data from raw suppliers

(6-(4-(Trifluoromethyl)phenyl)pyridin-3-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIDIN-3-YL)METHANOL

There total 6 articles about (6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIDIN-3-YL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methyl 6-(4-(trifluoromethyl)phenyl)nicotinate (356058-34-9) → 5-hydroxymethyl-2-(4-trifluoromethylphenyl)pyridine (356058-13-4)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

2-Chloro-5-hydroxymethylpyridine (21543-49-7) + 4-trifluoromethylphenylboronic acid (128796-39-4) → 5-hydroxymethyl-2-(4-trifluoromethylphenyl)pyridine (356058-13-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; Inert atmosphere;

Reference yield:

6-(4-(trifluoromethyl)phenyl)nicotinaldehyde (356058-14-5) + ethylmagnesium bromide (925-90-6) → 5-hydroxymethyl-2-(4-trifluoromethylphenyl)pyridine (356058-13-4) + 1-(6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)propan-1-ol (871250-36-1)

Guidance literature:

6-(4-(trifluoromethyl)phenyl)nicotinaldehyde; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 5 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

6-(4-(trifluoromethyl)phenyl)nicotinaldehyde

ethylmagnesium bromide

methyl 6-(4-(trifluoromethyl)phenyl)nicotinate

6-Chloronicotinic acid methyl ester

Downstream raw materials:

3-{4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-benzoylamino}-propionic acid methyl ester

5-(chloromethyl)-2-(4-(trifluoromethyl)phenyl)pyridine

6-(4-(trifluoromethyl)phenyl)nicotinaldehyde

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