tert-butyl di(but-3-en-1-yl)carbaMate

Base Information

• Chemical Name: tert-butyl di(but-3-en-1-yl)carbaMate
• CAS No.: 1211531-07-5
• Molecular Formula: C13H23NO2
• Molecular Weight: 225.331
• Hs Code.: 2924199090
• Mol file: 1211531-07-5.mol

Synonyms:tert-butyl di(but-3-en-1-yl)carbaMate

Chemical Property of tert-butyl di(but-3-en-1-yl)carbaMate

Chemical Property:

• PSA: 29.54000
• LogP: 3.37570

Purity/Quality:

99%min ^*data from raw suppliers

tert-ButylDi(but-3-en-1-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl di(but-3-en-1-yl)carbaMate

There total 2 articles about tert-butyl di(but-3-en-1-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + diallylamine (124-02-7) → tert-butyl di(but-3-en-1-yl)carbamate (1211531-07-5)

Guidance literature:

In methanol; at 0 - 20 ℃;

DOI:10.1021/jm100898v

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + di(but-3-en-1-yl)amine (18940-41-5) → tert-butyl di(but-3-en-1-yl)carbamate (1211531-07-5)

Guidance literature:

di-tert-butyl dicarbonate; di(but-3-en-1-yl)amine; With triethylamine; In tetrahydrofuran; for 1.5h;

With sodium hydroxide; In methanol; water; at 20 ℃; for 16h;

DOI:10.1021/ol9029808

Reference yield: 73.0%

tert-butyl di(but-3-en-1-yl)carbamate (1211531-07-5) → N-(tert-butoxycarbonyl)-3-pyrroline (73286-70-1)

Guidance literature:

With Grubbs catalyst first generation; In dichloromethane; at 20 ℃; for 17h;

DOI:10.1021/jm100898v

upstream raw materials:

di-tert-butyl dicarbonate

di(but-3-en-1-yl)amine

diallylamine

Downstream raw materials:

N-(tert-butoxycarbonyl)-3-pyrroline

ethene

N-Boc-1,2,3,6-tetrahydropyridine

(Z)-2,3,6,7-tetrahydro-1H-azepine hydrochloride

Refernces

• 1、 Wang, Xiaojing,Blackaby, Wesley,Allen, Vivienne,Chan, Grace Ka Yan,Chang, Jae H.,Chiang, Po-Chang,Diène, Coura,Drummond, Jason,Do, Steven,Fan, Eric,Harstad, Eric B.,Hodges, Alastair,Hu, Huiyong,Jia, Wei,Kofie, William,Kolesnikov, Aleksandr,Lyssikatos, Joseph P.,Ly, Justin,Matteucci, Mizio,Moffat, John G.,Munugalavadla, Veerendra,Murray, Jeremy,Nash, David,Noland, Cameron L.,Del Rosario, Geoff,Ross, Leanne,Rouse, Craig,Sharpe, Andrew,Slaga, Dionysos,Sun, Minghua,Tsui, Vickie,Wallweber, Heidi,Yu, Shang-Fan,Ebens, Allen J.. "Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma". . . Retrieved 2019/03/07.