Acetic acid, [[(3aR,4S,6R,6aS)-tetrahydro-2,2-diMethyl-6-[[(phenylMethoxy)carbonyl]aMino]-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, ethyl ester

Base Information

Chemical Name:Acetic acid, [[(3aR,4S,6R,6aS)-tetrahydro-2,2-diMethyl-6-[[(phenylMethoxy)carbonyl]aMino]-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, ethyl ester
CAS No.:866551-95-3
Molecular Formula:C₂₀H₂₇NO₇
Molecular Weight:393.437
Hs Code.:
Mol file:866551-95-3.mol

Synonyms:Acetic acid, [[(3aR,4S,6R,6aS)-tetrahydro-2,2-diMethyl-6-[[(phenylMethoxy)carbonyl]aMino]-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, ethyl ester

Suppliers and Price of Acetic acid, [[(3aR,4S,6R,6aS)-tetrahydro-2,2-diMethyl-6-[[(phenylMethoxy)carbonyl]aMino]-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl2-[[(3aR,4S,6R,6aS)-6-[(Benzyloxycarbonyl)amino]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]acetate
50mg
$ 315.00

ChemScene
Aceticacid,[[(3aR,4S,6R,6aS)-tetrahydro-2,2-dimethyl-6-[[(phenylmethoxy)carbonyl]amino]-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-,ethylester
500mg
$ 490.00

Total 6 raw suppliers

Chemical Property of Acetic acid, [[(3aR,4S,6R,6aS)-tetrahydro-2,2-diMethyl-6-[[(phenylMethoxy)carbonyl]aMino]-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, ethyl ester

Chemical Property:

Boiling Point:540.7±50.0 °C(Predicted)
PKA:11.26±0.60(Predicted)
PSA：92.32000
Density:1.24±0.1 g/cm3(Predicted)
LogP:2.54440
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

Ethyl2-[[(3aR,4S,6R,6aS)-6-[(Benzyloxycarbonyl)amino]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Ethyl 2-[[(3aR,4S,6R,6aS)-6-[(Benzyloxycarbonyl)amino]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]acetate is used as a reactant in the synthesis of Ticagrelor (T437700), a platelet aggregation inhibitor.

Technology Process of Acetic acid, [[(3aR,4S,6R,6aS)-tetrahydro-2,2-diMethyl-6-[[(phenylMethoxy)carbonyl]aMino]-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, ethyl ester

There total 30 articles about Acetic acid, [[(3aR,4S,6R,6aS)-tetrahydro-2,2-diMethyl-6-[[(phenylMethoxy)carbonyl]aMino]-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 274693-53-7
[3aS-(3aα,4α,6α,6aα)]-(tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)carbamic acid phenylmethyl ester

: 105-36-2
ethyl bromoacetate

: 866551-95-3
ethyl 2-(6-(benzyloxycarbonylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy) acetate

Guidance literature:: [3aS-(3aα,4α,6α,6aα)]-(tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)carbamic acid phenylmethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at -30 ℃; for 0.5h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 5.5h;

Reference yield: 34.0%

: 1423769-49-6
benzyl ((3aS,4R,6R,6aR)-6-hydroxy-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)carbamate

: 105-36-2
ethyl bromoacetate

: 866551-95-3
ethyl 2-(((3aR,4R,6R,6aS)-6-(((benzyloxy)carbonyl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d]-[1,3]dioxol-4-yl)oxy)acetate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃;
DOI:10.1016/j.tetlet.2015.09.074

Reference yield:

: 155899-66-4
(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

: 866551-95-3
ethyl 2-(6-(benzyloxycarbonylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy) acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / water; tetrahydrofuran / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -30 °C

2.2: 5.5 h / 20 °C

With sodium hydride; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;