4-CHLORO-6-(4-CHLOROPHENYL)THIENO[3,2-D]PYRIMIDINE

Base Information

Chemical Name:4-CHLORO-6-(4-CHLOROPHENYL)THIENO[3,2-D]PYRIMIDINE
CAS No.:681260-54-8
Molecular Formula:C₁₂H₆Cl₂N₂S
Molecular Weight:281.165
Hs Code.:2934999090
Mol file:681260-54-8.mol

Synonyms:4-CHLORO-6-(4-CHLOROPHENYL)THIENO[3,2-D]PYRIMIDINE;BUTTPARK 46\18-78

Suppliers and Price of 4-CHLORO-6-(4-CHLOROPHENYL)THIENO[3,2-D]PYRIMIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
4-Chloro-6-(4-chlorophenyl)thieno[3,2-d]pyrimidine
500mg
$ 353.00

AHH
4-Chloro-6-(4-chlorophenyl)thieno[3,2-d]pyrimidine 98%
5g
$ 830.00

Total 5 raw suppliers

Chemical Property of 4-CHLORO-6-(4-CHLOROPHENYL)THIENO[3,2-D]PYRIMIDINE

Chemical Property:

PSA：54.02000
LogP:4.66510

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-6-(4-chlorophenyl)thieno[3,2-d]pyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25-36
Safety Statements: 26-45

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-6-(4-CHLOROPHENYL)THIENO[3,2-D]PYRIMIDINE

There total 6 articles about 4-CHLORO-6-(4-CHLOROPHENYL)THIENO[3,2-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4(3H)-one

: 681260-54-8
4-chloro-6-(4-chlorophenyl)thieno[3,2-d]pyrimidine

Guidance literature:: With N,N-dimethyl-formamide; trichlorophosphate; at 110 ℃; for 6h;
DOI:10.1021/acs.jmedchem.8b01391

Reference yield:

: 16269-66-2
4-chlorothieno[3,2-d]pyrimidine

: 681260-54-8
4-chloro-6-(4-chlorophenyl)thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium; iodine / 2 h / -78 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; cesium fluoride / 1,4-dioxane; water / 3 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; iodine; sodium hydrogencarbonate; cesium fluoride; In 1,4-dioxane; water;
DOI:10.1016/j.bmcl.2011.07.069

Reference yield:

: 78583-86-5
(E)-3-Chloro-3-(4-chloro-phenyl)-acrylonitrile

: 681260-54-8
4-chloro-6-(4-chlorophenyl)thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 1 h

1.2: 5 h / 60 °C

2.1: 18 h / 180 °C

3.1: trichlorophosphate; N,N-dimethyl-formamide / 6 h / 110 °C

With sodium methylate; N,N-dimethyl-formamide; trichlorophosphate; In methanol;
DOI:10.1021/acs.jmedchem.8b01391