Benzenemethanamine, 4-chloro-3-fluoro-.alpha.-methyl-

Base Information

• Chemical Name: Benzenemethanamine, 4-chloro-3-fluoro-.alpha.-methyl-
• CAS No.: 787633-87-8
• Molecular Formula: C8H9ClFN
• Molecular Weight: 173.618
• Mol file: 787633-87-8.mol

Synonyms:Benzenemethanamine, 4-chloro-3-fluoro-.alpha.-methyl-;1-(4-CHLORO-3-FLUOROPHENYL)ETHAN-1-AMINE-HCL;1-(4-Chloro-3-fluorophenyl)ethanamine;1-(4-CHLORO-3-FLUOROPHENYL)ETHAN-1-AMINE;1-(4-CHLORO-3-FLUOROPHENYL)ETHANAMINE HYDROCHLORIDE

Chemical Property of Benzenemethanamine, 4-chloro-3-fluoro-.alpha.-methyl-

Chemical Property:

• PSA: 26.02000
• LogP: 3.19910

Purity/Quality:

98% ^*data from raw suppliers

1-(4-Chloro-3-fluorophenyl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, 4-chloro-3-fluoro-.alpha.-methyl-

There total 4 articles about Benzenemethanamine, 4-chloro-3-fluoro-.alpha.-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[1-(4-Chloro-3-fluoro-phenyl)-ethyl]-isoindole-1,3-dione (787633-86-7) → 1-(4-Chloro-3-fluoro-phenyl)-ethylamine (787633-87-8,1114559-11-3)

Guidance literature:

With hydrazine; In tetrahydrofuran; at 80 ℃; for 1h;

DOI:10.1016/j.bmcl.2006.04.009

Reference yield:

1-(4-chloro-3-fluoro-phenyl)-ethanol (339001-14-8) → 1-(4-Chloro-3-fluoro-phenyl)-ethylamine (787633-87-8,1114559-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₃P; DIAD / tetrahydrofuran / 0.5 h / -78 - 20 °C

2: hydrazine / tetrahydrofuran / 1 h / 80 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; hydrazine; In tetrahydrofuran; 1: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2006.04.009

Reference yield:

4-chloro-3-fluorobenzaldehyde (5527-95-7) → 1-(4-Chloro-3-fluoro-phenyl)-ethylamine (787633-87-8,1114559-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / -78 - 20 °C

2: Ph₃P; DIAD / tetrahydrofuran / 0.5 h / -78 - 20 °C

3: hydrazine / tetrahydrofuran / 1 h / 80 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; hydrazine; In tetrahydrofuran; 2: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2006.04.009

upstream raw materials:

2-[1-(4-Chloro-3-fluoro-phenyl)-ethyl]-isoindole-1,3-dione

1-(4-chloro-3-fluoro-phenyl)-ethanol

4-chloro-3-fluorobenzaldehyde

Downstream raw materials:

1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethylamine

N-[1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide

N-[1-(4-chloro-3-fluoro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide

Refernces

• 1、 Leonard, Kristi,Marugan, Juan Jose,Raboisson, Pierre,Calvo, Raul,Gushue, Joan M.,Koblish, Holly K.,Lattanze, Jennifer,Zhao, Shuyuan,Cummings, Maxwell D.,Player, Mark R.,Maroney, Anna C.,Lu, Tianbao. "Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity". . p. 3463 - 3468. Retrieved 2007/10/03.
• 2、 -. "Substituted 1,4-diazepines and uses thereof". Page 39. . Retrieved 2010/02/09.