339001-14-8

Basic information

• Product Name: 1-(4-chloro-3-fluoro-phenyl)-ethanol
• Synonyms: 1-(4-chloro-3-fluoro-phenyl)-ethanol
• CAS NO: 339001-14-8
• Molecular Weight: 174.602
• Mol File: 339001-14-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(4-chloro-3-fluoro-phenyl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chloro-3-fluoro-phenyl)-ethanol(339001-14-8)
• EPA Substance Registry System: 1-(4-chloro-3-fluoro-phenyl)-ethanol(339001-14-8)

Safety Data

• Hazardous Substances Data: 339001-14-8(Hazardous Substances Data)

Upstream product

• 75-16-1 methylmagnesium bromide 
• 5527-95-7 4-chloro-3-fluorobenzaldehyde 
• 917-54-4 methyllithium 

Downstream Products

• 787633-86-7 2-[1-(4-Chloro-3-fluoro-phenyl)-ethyl]-isoindole-1,3-dione 
• 231297-62-4 2-bromo-1-(4-chloro-3-fluorophenyl)ethan-1-one 
• 151945-84-5 4-acetyl-1-chloro-2-fluorobenzene 
• 900504-92-9 N-[1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide 
• 787633-88-9 N-[1-(4-chloro-3-fluoro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide 
• 900505-07-9 1-(4-chloro-5-fluoro-2-nitro-phenyl)-ethylamine 
• 787633-87-8 1-(4-Chloro-3-fluoro-phenyl)-ethylamine 

Relevant articles and documents

Oxazolidone derivatives as PR modulators

Compounds of the following structure are described: wherein R1, R2, R5, R6, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

The disruption of the p53-Hdm2 protein-protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.

SUBSTITUTED TETRAHYDROCARBAZOLE AND CYCLOPENTANOINDOLE DERIVATIVES

The present invention provides substituted tetrahydrocarbazole and cyclopentanoindole derivatives as antagonists of DP receptor, and as such are useful for the treatment of prostaglandin D2 mediated diseases such as rhinitis, asthma and nasal congestion.