7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine

Base Information

Chemical Name:7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine
CAS No.:99044-54-9
Molecular Formula:C13H11ClN4
Molecular Weight:258.71
Hs Code.:
Mol file:99044-54-9.mol

Synonyms:7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine;4-chloro-7-benzyl-7H-Pyrrolo[2,3-d]pyrimidin-2-amine

Suppliers and Price of 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine

Chemical Property:

PSA：56.73000
LogP:3.29640

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine

There total 8 articles about 7-Benzyl-4-chloro-7H-pyrrolo[2,3-D]pyriMidin-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 99044-54-9
2-amino-7-benzyl-4-chloropyrrolo<2,3-d>pyrimidine

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 25 deg C, 2.) DMF, 25 deg C, 24 h;
DOI:10.1002/jhet.5570330341

Reference yield:

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 99044-54-9
2-amino-7-benzyl-4-chloropyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / sodium ethoxyde / ethanol / 18 h / Ambient temperature

2: 57 percent / POCl₃/PCl₅/diethylaniline / 4 h / 120 °C

3: 1.) O₃; 2.) NaI-CH₃CO₂H / 1.) ethylacetate-methanol, -78 deg C

4: 77 percent / NH₄Cl / 3 h / Heating

5: triethylamine / butan-1-ol / 48 h / 100 °C

6: HCl (0.2N) / 72 h / Ambient temperature

With hydrogenchloride; phosphorus pentachloride; sodium ethanolate; ammonium chloride; ozone; acetic acid; triethylamine; N,N-diethylaniline; sodium iodide; trichlorophosphate; In ethanol; butan-1-ol;
DOI:10.1016/S0040-4039(00)98364-3

Reference yield:

: 97570-32-6
2-(2-amino-4,6-dichloropyrimidin-5-yl) acetaldehyde diethyl acetal

: 99044-54-9
2-amino-7-benzyl-4-chloropyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / butan-1-ol / 48 h / 100 °C

2: HCl (0.2N) / 72 h / Ambient temperature

With hydrogenchloride; triethylamine; In butan-1-ol;
DOI:10.1016/S0040-4039(00)98364-3