1,2-Bis-(4-hydroxyphenyl)-o-carborane

Base Information

• Chemical Name: 1,2-Bis-(4-hydroxyphenyl)-o-carborane
• CAS No.: 31177-92-1
• Molecular Formula: C14H20B10O2
• Molecular Weight: 318.33
• Mol file: 31177-92-1.mol

Synonyms:1,2-Bis-(4-hydroxyphenyl)-o-carborane;1,2-Bis(4-hydroxyphenyl)-1,2-dicarbadodecaborane(12);1,2-Bis(4-hydroxyphenyl)carborane;BE 360

Chemical Property of 1,2-Bis-(4-hydroxyphenyl)-o-carborane

Chemical Property:

• Melting Point: 123-125℃
• PSA: 40.46000
• LogP: -1.15120

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2-Bis(4-hydroxyphenyl)-o-carborane, also known as BE360, is an estrogen receptor modulator and produces antidepressant and antidementia effects.

Technology Process of 1,2-Bis-(4-hydroxyphenyl)-o-carborane

There total 1 articles about 1,2-Bis-(4-hydroxyphenyl)-o-carborane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,2-C2B10H10-1,2-(C6H4-4'-OCH3)2 (37100-45-1) → 1,2-C2B10H10-1,2-(C6H4-4'-OH)2 (31177-92-1)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1039/d0ra07264h

Reference yield: 76.0%

1,2-C2B10H10-1,2-(C6H4-4'-OH)2 (31177-92-1) + 5-(bromomethyl)-3,4,5-tris-(prop-2-yn-1-yloxy)benzene (1155417-74-5) → C46H44B10O8

Guidance literature:

With potassium carbonate; In acetone; at 90 ℃; for 17h; Inert atmosphere;

DOI:10.1039/d0ra07264h

Reference yield:

[Re(carbonyl)3(water)3]Br + 1,2-C2B10H10-1,2-(C6H4-4'-OH)2 (31177-92-1) → 2,1,8-[Re(CO)3(C2B9H9(C6H4OH)2)](1-)

Guidance literature:

With NaF; In ethanol; water; other Radiation; using microwaves at 200°C;

DOI:10.1021/ic0605928

upstream raw materials:

1,2-C₂B₁₀H₁₀-1,2-(C₆H₄-4'-OCH₃)2

Downstream raw materials:

1,2-C₂B₁₀H₁₀-1,2-Bis(4'-hydroxyphenyl) diglycidyl ether