Methyl 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoroMethyl)benzoate

Base Information

• Chemical Name: Methyl 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoroMethyl)benzoate
• CAS No.: 1045795-70-7
• Molecular Formula: C15H18BF3O4
• Molecular Weight: 330.1072296
• Mol file: 1045795-70-7.mol

Synonyms:Methyl 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoroMethyl)benzoate;4-Methoxycarbonyl-3-(trifluoromethyl)phenylboronic acid pinacol ester

Chemical Property of Methyl 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoroMethyl)benzoate

Chemical Property:

• PSA: 44.76000
• LogP: 2.79120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzoate ^*data from reagent suppliers

Safty Information:

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Technology Process of Methyl 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoroMethyl)benzoate

There total 1 articles about Methyl 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoroMethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-trifluoromethyl-benzoic acid methyl ester (344-96-7) + bis(pinacol)diborane (73183-34-3) → methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzoate (1045795-70-7) + methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzoate

Guidance literature:

With trans-(^iPrPNP)Co(H)₂BPin; In tetrahydrofuran; at 23 ℃; for 24h; Overall yield = 60 percent; Overall yield = 0.099 g; regioselective reaction; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1016/j.chempr.2020.11.017

Reference yield:

methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzoate (1045795-70-7) + 4-((((1R,3r,5S)-8-(4-bromothiazol-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)oxy)methyl)-5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole → methyl 4-(2-((1R,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)thiazol-4-yl)-2-(trifluoromethyl)benzoate

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 8h; Inert atmosphere;

Reference yield:

methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzoate (1045795-70-7) + 4-((((1R,3R,5S)8-(5-bromopyridin-2-yl)-8-azabicyclo[3.2.1]oct-3-yl)oxy)methyl)-5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole → methyl 4-(6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole- 4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)pyridin-3-yl)-2-(trifluoromethyl)benzoate

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 8h;

upstream raw materials:

2-trifluoromethyl-benzoic acid methyl ester

bis(pinacol)diborane

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