1H-INDENE,2-(BROMOMETHYL)-2,3-DIHYDRO

Base Information

• Chemical Name: 1H-INDENE,2-(BROMOMETHYL)-2,3-DIHYDRO
• CAS No.: 348080-87-5
• Molecular Formula: C₁₀H₁₁Br
• Molecular Weight: 211.101
• Hs Code.: 2903999090
• Mol file: 348080-87-5.mol

Synonyms:1H-INDENE,2-(BROMOMETHYL)-2,3-DIHYDRO;2-(BroMoMethyl)Indane

Chemical Property of 1H-INDENE,2-(BROMOMETHYL)-2,3-DIHYDRO

Chemical Property:

• Melting Point: 21 °C
• Boiling Point: 132 °C(Press: 11 Torr)
• PSA: 0.00000
• Density: 1.381±0.06 g/cm3(Predicted)
• LogP: 2.79630
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

2-(Bromomethyl)-2,3-dihydro-1H-indene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-INDENE,2-(BROMOMETHYL)-2,3-DIHYDRO

There total 4 articles about 1H-INDENE,2-(BROMOMETHYL)-2,3-DIHYDRO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(hydroxymethyl)indan (5445-45-4) → 2‐(bromomethyl)‐2,3‐dihydro‐1H‐indene (348080-87-5)

Guidance literature:

With sulfuric acid; hydrogen bromide;

DOI:10.1016/j.bmcl.2007.02.046

Reference yield: 30.0%

benzo[2,3]bicyclo[3.1.0]hexane (15677-15-3,148323-54-0,148323-57-3) → 2‐(bromomethyl)‐2,3‐dihydro‐1H‐indene (348080-87-5)

Guidance literature:

With water; boron tribromide; In dichloromethane; at 23 ℃; for 48h; regioselective reaction;

DOI:10.1039/d0sc02567d

Reference yield:

2-indanemethanol methanesulfonate (216220-22-3) → 2‐(bromomethyl)‐2,3‐dihydro‐1H‐indene (348080-87-5)

Guidance literature:

With lithium bromide; In acetone; Heating / reflux;

upstream raw materials:

2-(hydroxymethyl)indan

2-indanemethanol methanesulfonate

benzo[2,3]bicyclo[3.1.0]hexane

Refernces

• 1、 Bekkali, Younes,Thomson, David S.,Betageri, Raj,Emmanuel, Michel J.,Hao, Ming-Hong,Hickey, Eugene,Liu, Weimin,Patel, Usha,Ward, Yancey D.,Young, Erick R.R.,Nelson, Richard,Kukulka, Alison,Brown, Maryanne L.,Crane, Kathy,White, Della,Freeman, Dorothy M.,Labadia, Mark E.,Wildeson, Jessi,Spero, Denice M.. "Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors". . p. 2465 - 2469. Retrieved 2008/03/11.