5-Ethoxy-2-phenyloxazole-4-carbothioamide

Base Information

• Chemical Name: 5-Ethoxy-2-phenyloxazole-4-carbothioamide
• CAS No.: 128242-93-3
• Molecular Formula: C12H12N2O2S
• Molecular Weight: 0
• Mol file: 128242-93-3.mol

Synonyms:5-Ethoxy-2-phenyloxazole-4-carbothioamide

Chemical Property of 5-Ethoxy-2-phenyloxazole-4-carbothioamide

Chemical Property:

• PSA: 93.37000
• LogP: 3.07480

Purity/Quality:

98%min ^*data from raw suppliers

5-ETHOXY-2-PHENYLOXAZOLE-4-CARBOTHIOAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Ethoxy-2-phenyloxazole-4-carbothioamide

There total 2 articles about 5-Ethoxy-2-phenyloxazole-4-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-phenyl-4-(aminocarbonyl)-5-ethoxyoxazole (128242-87-5) → 2-phenyl-4-(aminothiocarbonyl)-5-ethoxyoxazole (128242-93-3)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jo00301a056

Reference yield:

2-phenyl-5-ethoxyoxazole-4-carboxylic acid chloride (54644-14-3) → 2-phenyl-4-(aminothiocarbonyl)-5-ethoxyoxazole (128242-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / aqueous ammonia / 0.5 h / Ambient temperature

2: 66 percent / 2,4-bis(methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (Lawesson's reagent) / tetrahydrofuran / 2 h / Heating

With Lawessons reagent; ammonium hydroxide; In tetrahydrofuran;

DOI:10.1021/jo00301a056

Reference yield: 87.0%

2-phenyl-4-(aminothiocarbonyl)-5-ethoxyoxazole (128242-93-3) → 5-amino-2-phenylthiazole-4-carboxylic acid ethyl ester (31785-06-5)

Guidance literature:

In toluene; for 17h; Heating;

DOI:10.1021/jo00301a056

upstream raw materials:

2-phenyl-4-(aminocarbonyl)-5-ethoxyoxazole

2-phenyl-5-ethoxyoxazole-4-carboxylic acid chloride

Downstream raw materials:

5-amino-2-phenylthiazole-4-carboxylic acid ethyl ester

Refernces