S-Ruxolitinib (INCB018424)

Base Information

Chemical Name:S-Ruxolitinib (INCB018424)
CAS No.:941685-37-6
Molecular Formula:C₁₇H₁₈N₆
Molecular Weight:306.37
Hs Code.:
Mol file:941685-37-6.mol

Synonyms:S-Ruxolitinib (INCB018424);Ruxolitinib (S enantioMer);(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]propanenitrile;S-Ruxolitinib;INCB 18424;1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-

Suppliers and Price of S-Ruxolitinib (INCB018424)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile(ent-Ruxolitinib)
100mg
$ 1465.00

DC Chemicals
S-Ruxolitinib(INCB018424) >98%
1 g
$ 1900.00

DC Chemicals
S-Ruxolitinib(INCB018424) >98%
250 mg
$ 950.00

Crysdot
RuxolitinibSenantiomer 98+%
5mg
$ 147.00

ChemScene
Ruxolitinib(Senantiomer) 99.92%
100mg
$ 192.00

ChemScene
Ruxolitinib(Senantiomer) 99.92%
50mg
$ 144.00

ChemScene
Ruxolitinib(Senantiomer) 99.92%
10mg
$ 84.00

ChemScene
Ruxolitinib(Senantiomer) 99.92%
5mg
$ 72.00

Biorbyt Ltd
S-Ruxolitinib (INCB018424) >98%
250 mg
$ 912.90

Biorbyt Ltd
S-Ruxolitinib (INCB018424) >98%
100 mg
$ 606.90

Total 23 raw suppliers

Chemical Property of S-Ruxolitinib (INCB018424)

Chemical Property:

PSA：83.18000
LogP:3.46638
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile(ent-Ruxolitinib) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. The opposite enantiomer of Ruxolitinib (R702000).

Technology Process of S-Ruxolitinib (INCB018424)

There total 92 articles about S-Ruxolitinib (INCB018424) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1146629-80-2
(R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

: 941678-49-5,941685-37-6
ruxolitinib

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; Product distribution / selectivity;

Reference yield: 92.1%

: 941685-40-1
(3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

: 941678-49-5,941685-37-6
ruxolitinib

Guidance literature:: (3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; With boron trifluoride diethyl etherate; In acetonitrile; at 60 - 70 ℃; for 5h;

With ammonium hydroxide; water; In acetonitrile; at 20 ℃; for 12h;