5-Acetyl-8-(phenylmethoxy)quinoline

Base Information

Chemical Name:5-Acetyl-8-(phenylmethoxy)quinoline
CAS No.:26872-48-0
Molecular Formula:C18H15NO2
Molecular Weight:277.323
Hs Code.:
DSSTox Substance ID:DTXSID90548264
Wikidata:Q82426907
Mol file:26872-48-0.mol

Synonyms:26872-48-0;5-Acetyl-8-(phenylmethoxy)quinoline;5-Acetyl-8-benzyloxyquinoline;1-(8-(Benzyloxy)quinolin-5-yl)ethanone;1-(8-phenylmethoxyquinolin-5-yl)ethanone;SCHEMBL3307110;DTXSID90548264;DWSIKCNONKHROY-UHFFFAOYSA-N;SB70478;1-[8-(Benzyloxy)quinolin-5-yl]ethan-1-one

Suppliers and Price of 5-Acetyl-8-(phenylmethoxy)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Acetyl-8-(phenylmethoxy)quinoline
250mg
$ 725.00

TRC
5-Acetyl-8-(phenylmethoxy)quinoline
100mg
$ 305.00

Medical Isotopes, Inc.
5-Acetyl-8-(phenylmethoxy)quinoline
500 mg
$ 2700.00

Biosynth Carbosynth
5-Acetyl-8-(phenylmethoxy)quinoline
500 mg
$ 1640.00

Biosynth Carbosynth
5-Acetyl-8-(phenylmethoxy)quinoline
250 mg
$ 902.50

Biosynth Carbosynth
5-Acetyl-8-(phenylmethoxy)quinoline
50 mg
$ 272.50

Biosynth Carbosynth
5-Acetyl-8-(phenylmethoxy)quinoline
25 mg
$ 150.00

AK Scientific
5-Acetyl-8-benzyloxyquinoline
100mg
$ 719.00

Total 4 raw suppliers

Chemical Property of 5-Acetyl-8-(phenylmethoxy)quinoline

Chemical Property:

Melting Point:131-133 °C
Boiling Point:479.9±30.0 °C(Predicted)
PKA:2.12±0.29(Predicted)
PSA：39.19000
Density:1.190±0.06 g/cm3(Predicted)
LogP:4.01640
Solubility.:Chloroform
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:277.110278721
Heavy Atom Count:21
Complexity:351

Purity/Quality:

97% ^*data from raw suppliers

5-Acetyl-8-(phenylmethoxy)quinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=C2C=CC=NC2=C(C=C1)OCC3=CC=CC=C3
Uses 5-Acetyl-8-(phenylMethoxy)quinoline is used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

Technology Process of 5-Acetyl-8-(phenylmethoxy)quinoline

There total 3 articles about 5-Acetyl-8-(phenylmethoxy)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2598-31-4
5-acetyl-8-hydroxyquinoline

: 100-39-0
benzyl bromide

: 26872-48-0
1-(8-benzyloxyquinolin-5-yl)ethanone

Guidance literature:: 5-acetyl-8-hydroxyquinoline; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; for 24h;
DOI:10.3762/bjoc.10.212

Reference yield:

: 57434-96-5
5-acetyl-8-hydroxyquinoline hydrochloride

: 100-44-7
benzyl chloride

: 26872-48-0
1-(8-benzyloxyquinolin-5-yl)ethanone

Guidance literature:: With potassium carbonate; In N-methyl-acetamide; water;

Reference yield:

: 148-24-3,24804-14-6
8-quinolinol

: 26872-48-0
1-(8-benzyloxyquinolin-5-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / nitrobenzene / 14 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

2.2: 24 h

With aluminum (III) chloride; potassium carbonate; In nitrobenzene; N,N-dimethyl-formamide; 1.1: |Friedel-Crafts Acylation;
DOI:10.3762/bjoc.10.212