Desflurane

Base Information

• Chemical Name: Desflurane
• CAS No.: 57041-67-5
• Molecular Formula: C3H2F6O
• Molecular Weight: 168.039
• Hs Code.: 2909191800
• European Community (EC) Number: 688-023-8
• ICSC Number: 1437
• UNII: CRS35BZ94Q
• DSSTox Substance ID: DTXSID80866606
• Nikkaji Number: J444.212A
• Wikipedia: Desflurane
• Wikidata: Q419383
• NCI Thesaurus Code: C47472
• RXCUI: 27340
• Pharos Ligand ID: X69MY3W9KW6B
• Metabolomics Workbench ID: 145911
• ChEMBL ID: CHEMBL1200733
• Mol file: 57041-67-5.mol

Synonyms:1,2,2,2-Tetrafluoroethyl difluoromethyl ether;desflurane;I 653;I-653;I653;Suprane

Chemical Property of Desflurane

Chemical Property:

• Vapor Pressure: 1180mmHg at 25°C
• Refractive Index: 1.249
• Boiling Point: 12.4 °C at 760 mmHg
• PSA: 9.23000
• Density: 1.425g/cm³
• LogP: 2.08350
• Solubility.: Practically insoluble in water, miscible with anhydrous ethanol.
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 168.00098366
• Heavy Atom Count: 10
• Complexity: 97.7

Purity/Quality:

99% ^*data from raw suppliers

1,2,2,2-Tetrafluoroethyl difluoromethyl ether 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 23

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Drug Classes: Anesthetics, Halogenated
• Canonical SMILES: C(C(F)(F)F)(OC(F)F)F
• Recent ClinicalTrials: Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery
• Recent EU Clinical Trials: The effect of desflurane versus Sevoflurane on postoperative recovery in patients undergoing minor- to moderate-risk noncardiac surgery - a prospective double-blinded randomized clinical trial
• Recent NIPH Clinical Trials: Study on postoperative analgesia and delirium after lung surgery
• Inhalation Risk: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is irritating to the eyes and skin. The vapour is irritating to the respiratory tract. The substance may cause effects on the central nervous system and cardiovascular system. Exposure at high levels could cause unconsciousness.
• Description: Desflurane is a new inhalation anesthetic introduced for induction and maintenance of general anesthesia in adults. Due to reports of respiratory irritation, desflurane may be used only for maintenance in children. Although almost structurally identical to isoflurane, a halogen replacement gives desflurane an improved pharmacokinetic profile. It is less soluble in blood and tissue and produces a fast onset of action and a more rapid recovery from anesthesia.
• Uses: Anesthetic.
• Biological Functions: Desflurane (Suprane) shares most of the pharmacological properties of isoflurane. Desflurane has low tissue and blood solubility compared with other halogenated hydrocarbons, and its anesthetic partial pressure is thus established more rapidly. Recovery is similarly prompt when the patient is switched to room air or oxygen. Desflurane’s popularity for outpatient procedures stems from its rapid onset and prompt elimination from the body by exhalation. A disadvantage is that desflurane irritates the respiratory tract; thus, it is not preferred for induction of anesthesia using an inhalational technique. However, desflurane may be used to maintain anesthesia after induction with an alternative IV or inhalational agent, preserving the advantage of rapid recovery. Desflurane, like other halogenated hydrocarbon anesthetics, causes a decrease in blood pressure.The reduced pressure occurs primarily as a consequence of decreased vascular resistance, and since cardiac output is well maintained, tissue perfusion is preserved. Desflurane stimulates the sympathetic nervous system and causes abrupt transient tachycardia during induction or as the concentration of the agent is raised to meet the patient’s changing needs. Desflurane causes an increase in the rate of ventilation, a decrease in tidal volume, and a decrease in minute volume as inspired concentrations only slightly exceed 1 MAC. Thus should anesthesiologists require desflurane to be administered near or above MAC levels, patients are likely to have marked reductions in PCO2.

Technology Process of Desflurane

There total 2 articles about Desflurane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.7%

isoflurane (26675-46-7,133098-05-2) → 1,1,1,2-tetrafluoro-2-chloroethane (2837-89-0) + desflurane (57041-67-5)

Guidance literature:

With pyridine-hydrogen fluoride complex; hydrogen fluoride; at 320 ℃; Temperature; Inert atmosphere;

Reference yield:

1,2,2,2-tetrafluoroethyl dichloromethyl ether (56885-29-1) → rac-1,2,2,2-Tetrafluoroethyl chlorofluoromethyl ether (56885-28-0) + desflurane (57041-67-5)

Guidance literature:

With hydrogen fluoride; at 80 ℃; for 8h; under 7500.75 Torr; Pressure; Temperature; Cooling with ice;

upstream raw materials:

1,2,2,2-tetrafluoroethyl dichloromethyl ether

isoflurane

Refernces