diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Base Information

Chemical Name:diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate
CAS No.:1035262-26-0
Molecular Formula:C19H22Cl2O6
Molecular Weight:417.28
Hs Code.:
Mol file:1035262-26-0.mol

Synonyms:diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Chemical Property:

PSA：78.90000
LogP:3.35310

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

There total 4 articles about diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1040860-93-2
C₁₂H₁₁Cl₃O₂

: 105-53-3
diethyl malonate

: 1035262-26-0
diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: diethyl malonate; With tetrachloromethane; magnesium; In tetrahydrofuran; ethanol; at 70 ℃; for 1h;

C₁₂H₁₁Cl₃O₂; In tetrahydrofuran; diethyl ether; ethanol; at 20 ℃; for 1h;

Reference yield:

: 1035262-25-9
4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carboxylic acid

: 1035262-26-0
diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 1 h / 65 °C

2.1: tetrachloromethane; magnesium / tetrahydrofuran; ethanol / 1 h / 70 °C

2.2: 1 h / 20 °C

With tetrachloromethane; thionyl chloride; magnesium; In tetrahydrofuran; ethanol;

Reference yield:

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 1035262-26-0
diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 1 h / 0 °C

2.1: sulfuric acid; water / 1 h / 180 °C

3.1: thionyl chloride / 1 h / 65 °C

4.1: tetrachloromethane; magnesium / tetrahydrofuran; ethanol / 1 h / 70 °C

4.2: 1 h / 20 °C

With tetrachloromethane; thionyl chloride; sulfuric acid; water; sodium hydride; magnesium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol;