4-(Pyrazin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(Pyrazin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:301226-90-4
Molecular Formula:C14H22N4O2
Molecular Weight:278.35008
Hs Code.:2933399990
Mol file:301226-90-4.mol

Synonyms:4-(Pyrazin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-(Pyrazin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(pyrazin-2-ylamino)piperidine-1-carboxylate 95+%
1g
$ 532.00

Chemenu
tert-Butyl4-(pyrazin-2-ylamino)piperidine-1-carboxylate 95%
1g
$ 497.00

Alichem
tert-Butyl4-(pyrazin-2-ylamino)piperidine-1-carboxylate
1g
$ 438.60

Total 5 raw suppliers

Chemical Property of 4-(Pyrazin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Boiling Point:416.7±45.0 °C(Predicted)
PKA:3.08±0.10(Predicted)
PSA：67.35000
Density:1.179±0.06 g/cm3(Predicted)
LogP:2.29890

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(pyrazin-2-ylamino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(Pyrazin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-(Pyrazin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 14508-49-7
2-chloropyrazin

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 301226-90-4
1-(t-Butoxycarbonyl)-4-(N-pyrazin-2-yl)aminopiperidine

Guidance literature:: With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; palladium diacetate; In toluene; at 70 ℃; sealed tube;

Reference yield: 43.0%

: 5049-61-6
2-Aminopyrazine

: 301673-14-3
tert-butyl 4-iodopiperidine-1-carboxylate

: 301226-90-4
1-(t-Butoxycarbonyl)-4-(N-pyrazin-2-yl)aminopiperidine

Guidance literature:: With tributyl-amine; trimethylsilyl(cumyl) peroxide; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; copper(l) chloride; In acetonitrile; tert-butyl alcohol; at 0 ℃; for 1h; Sealed tube; Inert atmosphere;
DOI:10.1038/s41929-021-00652-8