3-Hydroxy-2-(3-methoxyphenyl)prop-2-enenitrile

Base Information

Chemical Name:3-Hydroxy-2-(3-methoxyphenyl)prop-2-enenitrile
CAS No.:656829-44-6
Molecular Formula:C10H9NO2
Molecular Weight:175.187
Hs Code.:
DSSTox Substance ID:DTXSID20308090
Mol file:656829-44-6.mol

Synonyms:Maybridge3_000649;656829-44-6;3-hydroxy-2-(3-methoxyphenyl)prop-2-enenitrile;DTXSID20308090

Suppliers and Price of 3-Hydroxy-2-(3-methoxyphenyl)prop-2-enenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Hydroxy-2-(3-methoxyphenyl)prop-2-enenitrile

Chemical Property:

PSA：53.25000
LogP:2.11768
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:175.063328530
Heavy Atom Count:13
Complexity:239

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C(=CO)C#N

Technology Process of 3-Hydroxy-2-(3-methoxyphenyl)prop-2-enenitrile

There total 1 articles about 3-Hydroxy-2-(3-methoxyphenyl)prop-2-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-31-3
Methyl formate

: 19924-43-7
3-methoxyphenylacetonitrile

: 656829-44-6
C₁₀H₉NO₂

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.08.027

Reference yield:

: 656829-44-6
C₁₀H₉NO₂

: 77-78-1
dimethyl sulfate

: 1622933-23-6
C₁₁H₁₁NO₂

Guidance literature:: C₁₀H₉NO₂; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

dimethyl sulfate; In tetrahydrofuran; at 40 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.08.027

Reference yield:

: 656829-44-6
C₁₀H₉NO₂

: 679425-85-5
methyl 3-amino-4-(3-methoxyphenyl)-2-thiophene carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 40 °C / Inert atmosphere

2.1: sodium methylate / methanol / 65 °C / Inert atmosphere

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2014.08.027