Acetyllysine

Base Information Edit

Chemical Name:Acetyllysine
CAS No.:692-04-6
Molecular Formula:C8H16N2O3
Molecular Weight:188.227
Hs Code.:29241900
Wikipedia:Acetyllysine
Mol file:692-04-6.mol

Synonyms:acetyllysine;S-6-acetamido-2-aminohexanoic acid;CHEBI:58260;N(6)-acetyl-L-lysine zwitterion;(2S)-6-acetamido-2-ammoniohexanoate;(2S)-6-acetamido-2-azaniumylhexanoate

Suppliers and Price of Acetyllysine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Nepsilon-Acetyl-L-lysine
2g
$ 333.00

Usbiological
N-Epsilon-acetyl-l-lysine
1g
$ 312.00

TRC
N-Epsilon-acetyl-l-lysine
1g
$ 55.00

TCI Chemical
Nε-Acetyl-L-lysine >98.0%(T)
1g
$ 40.00

Sigma-Aldrich
Nω-Acetyl-L-lysine
1g
$ 86.60

Sigma-Aldrich
Nω-Acetyl-L-lysine
5g
$ 260.00

Frontier Specialty Chemicals
N-epsilon-Acetyl-L-lysine 99%
5g
$ 185.00

Frontier Specialty Chemicals
N-epsilon-Acetyl-L-lysine 99%
1g
$ 46.00

Crysdot
H-Lys(Ac)-OH 97%
25g
$ 189.00

ChemScene
Nepsilon-Acetyl-L-lysine ≥97.0%
100mg
$ 50.00

Total 49 raw suppliers

Chemical Property of Acetyllysine Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:4.76E-09mmHg at 25°C
Melting Point:250 °C
Refractive Index:1.49
Boiling Point:442 °C at 760 mmHg
PKA:2.53±0.24(Predicted)
Flash Point:221.1 °C
PSA：92.42000
Density:1.139 g/cm³
LogP:0.79590
Storage Temp.:−20°C
Sensitive.:Hygroscopic
Solubility.:Aqueous Base (Slightly), Water (Slightly)
Water Solubility.:Soluble in water (miscible), and 80% acetic acid (50 mg/ml).
XLogP3:-2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:188.11609238
Heavy Atom Count:13
Complexity:177

Purity/Quality:

99% ^*data from raw suppliers

Nepsilon-Acetyl-L-lysine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 24/25-36-26

MSDS Files:: Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(=O)NCCCCC(C(=O)[O-])[NH3+]
Isomeric SMILES:CC(=O)NCCCC[C@@H](C(=O)[O-])[NH3+]
Description Acetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. There are multiple forms of acetyllysine - this article refers to N-ε-acetyl-L-lysine. The other form is N-α-acetyl-Llysine. In proteins, the acetylation of lysine residues is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Non-histone proteins are acetylated as well. Unlike the functionally similar methyllysine, acetyllysine does not carry a positive charge on its side chain. Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines. Acetyllysine can be synthesized from lysine by the selective acetylation of the terminal amine group.
Uses N-Epsilon-acetyl-l-lysine is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.

Technology Process of Acetyllysine

There total 19 articles about Acetyllysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%