22α-Ethyl-15,16-dimethoxy-4,25-secoobscurinervan-4-one

Base Information

• Chemical Name: 22α-Ethyl-15,16-dimethoxy-4,25-secoobscurinervan-4-one
• CAS No.: 54658-09-2
• Molecular Formula: C25H34N2O5
• Molecular Weight: 442.55
• Mol file: 54658-09-2.mol

Synonyms:22α-Ethyl-15,16-dimethoxy-4,25-secoobscurinervan-4-one

Chemical Property of 22α-Ethyl-15,16-dimethoxy-4,25-secoobscurinervan-4-one

Chemical Property:

• PSA: 71.47000
• LogP: 2.51380

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 22α-Ethyl-15,16-dimethoxy-4,25-secoobscurinervan-4-one

There total 4 articles about 22α-Ethyl-15,16-dimethoxy-4,25-secoobscurinervan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

obscurinervine (7097-00-9) → Dihydro-obscurinervinolon (54658-09-2)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd-C / ethyl acetate

2: LiAlH₄ / diethyl ether / Heating

3: benzene / 1 h / 0 °C

4: (i) DCC, DMSO, H₃PO₄, (ii) K₂CO₃, MeOH

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In diethyl ether; ethyl acetate; benzene;

DOI:10.1021/ja01066a031

Reference yield:

obscurinervine (7097-01-0) → Dihydro-obscurinervinolon (54658-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlH₄ / diethyl ether / Heating

2: benzene / 1 h / 0 °C

3: (i) DCC, DMSO, H₃PO₄, (ii) K₂CO₃, MeOH

With lithium aluminium tetrahydride; In diethyl ether; benzene;

DOI:10.1021/ja01066a031

Reference yield:

5'α-ethyl-15,16-dimethoxy-5',6'-dihydro-[1,4]oxazino[4',3',2':1,18,17]aspidospermidine-4β,21-diol (54658-11-6) → Dihydro-obscurinervinolon (54658-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 1 h / 0 °C

2: (i) DCC, DMSO, H₃PO₄, (ii) K₂CO₃, MeOH

In benzene;

DOI:10.1021/ja01066a031

upstream raw materials:

21-acetoxy-5'α-ethyl-15,16-dimethoxy-5',6'-dihydro-[1,4]oxazino[4',3',2':1,18,17]aspidospermidin-4β-ol

5'α-ethyl-15,16-dimethoxy-5',6'-dihydro-[1,4]oxazino[4',3',2':1,18,17]aspidospermidine-4β,21-diol

obscurinervine

obscurinervine