2-((tert-butoxycarbonyl)amino)-3-oxooctahydroindolizine-5-carboxylic acid

Base Information

Chemical Name:2-((tert-butoxycarbonyl)amino)-3-oxooctahydroindolizine-5-carboxylic acid
CAS No.:215182-89-1
Molecular Formula:C14H22N2O5
Molecular Weight:298.339
Hs Code.:
Mol file:215182-89-1.mol

Synonyms:2-((tert-butoxycarbonyl)amino)-3-oxooctahydroindolizine-5-carboxylic acid

Suppliers and Price of 2-((tert-butoxycarbonyl)amino)-3-oxooctahydroindolizine-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 2-((tert-butoxycarbonyl)amino)-3-oxooctahydroindolizine-5-carboxylic acid

Chemical Property:

PSA：95.94000
LogP:1.44650

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-((tert-butoxycarbonyl)amino)-3-oxooctahydroindolizine-5-carboxylic acid

There total 1 articles about 2-((tert-butoxycarbonyl)amino)-3-oxooctahydroindolizine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 524958-63-2
(2S,5S)-2-tert-Butoxycarbonylamino-3-oxo-octahydro-indolizine-5-carboxylic acid methyl ester

: 215182-89-1
(2S,5S,8aR)-2-(tert-Butoxycarbonylamino)-3-oxooctahydroindolizine-5-carboxylic acid

: (2S,5S,8aS)-2-tert-Butoxycarbonylamino-3-oxo-octahydro-indolizine-5-carboxylic acid

Guidance literature:: With potassium trimethylsilonate; In diethyl ether; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jo9814602

Reference yield:

: 108-24-7
acetic anhydride

: 127095-92-5
N-tert-butoxycarbonyl-D-cyclohexylalanine

: 57292-44-1
N-Boc-D-(4-Cl)Phe-OH

: 215182-89-1
(2S,5S,8aR)-2-(tert-Butoxycarbonylamino)-3-oxooctahydroindolizine-5-carboxylic acid

: (R)-5-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentanoic acid

: (2S,5S,8aR)-2-[(R)-2-((S)-2-Acetylamino-5-guanidino-pentanoylamino)-3-cyclohexyl-propionylamino]-3-oxo-octahydro-indolizine-5-carboxylic acid {(R)-1-[(R)-1-carbamoyl-2-(4-chloro-phenyl)-ethylcarbamoyl]-4-guanidino-butyl}-amide

Guidance literature:: Multistep reaction.;
DOI:10.1021/jm020078l

Reference yield:

: 1329063-33-3
(3S)-β-homophenylalanine benzyl ester hydrochloride

: 215182-89-1
(2S,5S,8aR)-2-(tert-Butoxycarbonylamino)-3-oxooctahydroindolizine-5-carboxylic acid

: 1329063-20-8
C₃₅H₃₉N₅O₆

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / Inert atmosphere; solid phase reaction

1.2: Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen; acetic acid / ethanol / 760.05 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; acetic acid; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm200608k